SERS detection and antibacterial treatment of bacterial infections
Shanshan Lin a,1, Zhun Nie b,c,1, Yanlong Xing b,c,*, Rui Wang b,c,*,
Fabiao Yu b,c,*
a Jiangyin Center for Disease Control and Prevention, Wuxi 214431, China
b Key Laboratory of Emergency and Trauma, Ministry of Education, Key Laboratory of Hainan Trauma and Disaster Rescue, Key Laboratory of Haikou Trauma, The First
Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou 571199, China
c Engineering Research Center for Hainan Bio-Smart Materials and Bio-Medical Devices, Key Laboratory of Hainan Functional Materials and Molecular Imaging, College
of Emergency and Trauma, Hainan Medical University, Haikou, China
ighlights
•Label-free and label-based SERS enables rapid, sensitive bacterial detection.
•Nanomaterial-based therapy combats infections and antibiotic resistance.
•Synergistic SERS and therapy platforms show clinical translation potential.
Abstract
The development situation of clinical bacterial resistance is becoming increasing severe, posing a serious threat to human survival. Timely identification of bacterial infections and effective antimicrobial treatments are both urgent needs in the current situation. Surface-enhanced Raman Scattering (SERS) provides a potential solution for the diagnosis of bacterial infections by highly sensitive characterization of molecular structure information. In addition, antimicrobial therapy based on nanomaterials has also been widely explored because of its excellent antibacterial effects and low susceptibility to bacterial resistance. Firstly, the progress of SERS was reviewed in the diagnosis of bacterial infections from the two aspects of label-free detection and label detection respectively, and then various effective antibacterial strategies for based on nanomaterials were summarized. It is hoped that SERS detection and antibacterial nanotherapeutic methods will provide useful reference for the diagnosis and treatment of clinical bacterial infections.
