Fluorescence image-guided tumour surgery

荧光图像引导下的肿瘤手术

主讲人：赵桂玲
Nature Reviews Bioengineering Pub Date : 2023-02-03 , DOI: 10.1038/s44222-022-00017-1

ABSTRACT:

Intraoperative fuorescent imaging can provide real-time identifcation

of tumours, lymph nodes, nerves and other healthy and malignant tissues during oncological surgery, contributing to better surgical outcomes. Various fuorescent probes have been clinically approved for surgical applications, improving tumour resection precision and preventing iatrogenic injury. In this Review, we discuss the development and application of fuorescent probes for image-guided surgery, including systemically and locally applied probes that are either non-targeted or targeted to specifc tumours and tissues. We discuss the optimization and clinical potential of these probes, and highlight their current and future applications in oncological surgery. In addition, we examine the hardware of fuorescence imaging equipment, and discuss how artifcial intelligence can enable real-time quantifcation to guide surgical decision-making. Finally, we highlight the remaining challenges in the feld of image-guided surgery, including the need for standardization to achieve regulatory approval of new probes, and the required team efort for new probe development。

摘要：

   术中荧光成像可在肿瘤手术中实时识别肿瘤、淋巴结、神经等健康和恶性组织，有助于更好的手术效果。各种荧光树脂探针已被临床批准用于外科应用，提高肿瘤切除的精度和预防医源性损伤。在这篇综述中，我们讨论了荧光探针在图像引导手术中的发展和应用，包括系统和局部应用的非靶向或靶向特定肿瘤和组织的探针。我们讨论了这些探针的优化和临床潜力，并强调了它们目前和未来在肿瘤手术中的应用。此外，我们还研究了荧光成像设备的硬件，并讨论了人工智能如何实现实时定量来指导手术决策。最后，我们强调了图像引导手术领域中的剩余挑战，包括需要标准化以获得监管批准，以及新探针开发所需的团队。