姓名：姜丹莉
邮箱：hy0322007@muhn.edu.cn
教育经历：
2005年9月-2009年6月，南昌大学，生命科学学院，学士
2009年9月-2012年6月，汕头大学，海洋生物研究所，硕士
2012年9月-2017年6月，浙江大学，动物科学学院，博士
工作经历：
2017年9月-2018年7月，中山大学，生命科学学院，博士后
2018年8月-2021年8月，美国匹兹堡大学，医学院，博士后
研究方向：
基于大规模GWAS数据，系统性筛选与衰老疾病相关的功能性非编码SNP，鉴定其特异性结合的调控蛋白（如转录因子），并深入阐释这些变异如何通过破坏基因调控网络影响疾病风险；2）利用UK Biobank等大型生物库资源，挖掘与人类复杂疾病及健康表型相关的新型遗传变异。最终目标是揭示疾病的分子遗传基础，并为精准医学发现新的干预靶点。
研究内容：
1. 急性淋巴细胞白血病相关位点CDKN2A/B的功能性单核苷酸多肽性(fSNP)的调控机制研究
2. 克隆造血功能性单核苷酸多肽性(fSNP)的筛选及调控机制研究
代表性学术论文（第一作者或通讯）
1. Danli Jiang1, Wei Sun1, Ting Wu, Meijuan Zou, Sathish Babu Vasamsetti, Xiaoyu Zhang, Yihan Zhao, Sina Tavakoli, Partha Dutta, Jonathan Florentin, Stephen Y. Chan, Di Wu, Jing Cui, Toren Finkel, Gang Li*. “Post-GWAS functional analysis of the CDKN2A/B locus identifies CUX1 as a regulator of p16INK4a expression and cellular senescence.” Nature Aging, 2022, J doi. 10.1038/s43587-022-00177-0.
2. Ting Wu1, Yuwei Wu1, Danli Jiang1, Wei Sun, Meijuan Zou, Sathish Babu Vasamsetti, Partha Dutta, Steven A. Leers, Wu Di, Gang Li. “SATB2, coordinated with CUX1, regulates IL-1β-induced senescence-like phenotype in endothelial cells by fine-tuning the atherosclerosis-associated p16INK4a expression.”Aging Cell, 2(2023):e13765.
3. Yuwei Wu1, Danli Jiang1, Qingliu, Shaoyang, Wei Sun, Gang Li*. Cathepsin L induces cellular senescence by upregulating CUX1 and p16INK4a. Aging, 16 (2024): 10749-10764.
4. Danli Jiang 1, Xiaohui Gu1, Bijun Li, Zongxian Zhu, Huiqin, Zining Meng, Haoran Lin, and Junhong Xia. "Identifying a long QTL cluster across chrLG18 associated with salt tolerance in tilapia using GWAS and QTL-seq." Marine Biotechnology 21, no. 2 (2019): 250-261.
5. Gu, Xiaohui1, Danli Jiang1, Yan Huang, Bijun Li, Chaohao Chen, Haoran Lin, and Junhong Xia. "Identifying a major QTL associated with salinity tolerance in Nile tilapia using QTL-Seq." Marine biotechnology 20, no. 1 (2018): 98-107.
6. Danli Jiang, Hongkuan Zhang, Runlin Liu, Huaiping Zheng, Helu Liu*. Srebp-1 bridges gonad development and lipid accumulation by regulating lipogenesis in noble scallop Chlamys nobilis. International Journal of Biological Macromolecules, 279 (2024), 135094.
主持过的科研项目（项目名称；项目编号；级别；经费；起止日期）
1. 海南省自然科学青年基金，克隆造血功能性单核苷酸多态性（fSNP）的筛选及调控机制研究，823QN247, 2023.03 - 2026.02, 6万，在研
2. 海南省自然科学基金高层次人才项目，RBPJ通过结合SNP rs2811709对急性淋巴细胞白血病易感基因座CDKN2A/B的转录调控研究，824RC515, 2024.01-2026.12, 10万，在研
3. 国家自然科学地区基金，RBPJ/p16INK4a信号轴在急性淋巴细胞白血病中的作用及机制研究，82460038，2025.01-2028.12, 32万，立项
Name: Danli Jiang
Email: hy0322007@muhn.edu.cn
Education background:
2005/9-2009/6, Nanchang University, College of Life Science, Bachelor
2009/9-2012/6, Shantou University, Marine Biology Institute, Master
2012/9-2017/6, Zhejiang University, College of Animal Science, PhD
Work experience:
2017/9-2018/7，Sun Yat-sen University, College of Life Science, Post-doc
2018/8-2021/8，Pittsburgh University, Medical College, Post-doc
Research Area:
post-GWAS analysis on human disease;
Molecular mechanisms of cellular senescence
Research Interests:
1. Regulatory mechanisms of functional single nucleotide polymorphisms (fSNP) on CDKN2A/B loci associated with acute lymphoblastic leukemia；
2. Identification and characterization of functional single nucleotide polymorphisms (fSNP) associated with clonal hematopoiesis
Selected publications:
1. Danli Jiang1, Wei Sun1, Ting Wu, Meijuan Zou, Sathish Babu Vasamsetti, Xiaoyu Zhang, Yihan Zhao, Sina Tavakoli, Partha Dutta, Jonathan Florentin, Stephen Y. Chan, Di Wu, Jing Cui, Toren Finkel, Gang Li*. “Post-GWAS functional analysis of the CDKN2A/B locus identifies CUX1 as a regulator of p16INK4a expression and cellular senescence.” Nature Aging, 2022, J doi. 10.1038/s43587-022-00177-0.
2. Ting Wu1, Yuwei Wu1, Danli Jiang1, Wei Sun, Meijuan Zou, Sathish Babu Vasamsetti, Partha Dutta, Steven A. Leers, Wu Di, Gang Li. “SATB2, coordinated with CUX1, regulates IL-1β-induced senescence-like phenotype in endothelial cells by fine-tuning the atherosclerosis-associated p16INK4a expression.”Aging Cell, 2(2023):e13765.
3. Yuwei Wu1, Danli Jiang1, Qingliu, Shaoyang, Wei Sun, Gang Li*. Cathepsin L induces cellular senescence by upregulating CUX1 and p16INK4a. Aging, 16 (2024): 10749-10764.
4. Danli Jiang 1, Xiaohui Gu1, Bijun Li, Zongxian Zhu, Huiqin, Zining Meng, Haoran Lin, and Junhong Xia. "Identifying a long QTL cluster across chrLG18 associated with salt tolerance in tilapia using GWAS and QTL-seq." Marine Biotechnology 21, no. 2 (2019): 250-261.
5. Gu, Xiaohui1, Danli Jiang1, Yan Huang, Bijun Li, Chaohao Chen, Haoran Lin, and Junhong Xia. "Identifying a major QTL associated with salinity tolerance in Nile tilapia using QTL-Seq." Marine biotechnology 20, no. 1 (2018): 98-107.
6. Danli Jiang, Hongkuan Zhang, Runlin Liu, Huaiping Zheng, Helu Liu*. Srebp-1 bridges gonad development and lipid accumulation by regulating lipogenesis in noble scallop Chlamys nobilis. International Journal of Biological Macromolecules, 279 (2024), 135094.
