江一舟  副研究员

邮箱：jiangyizhou@muhn.edu.cn

教育背景

2017.09-2022.06  澳门大学&南方科技大学, 博士

2013.09-2017.06   南方科技大学，学士

工作经历

2022.09-2022.12  北京大学，前沿交叉学科研究院

2022.12至今  海南医科大学, 衰老与肿瘤国际研究中心，副研究员

主要荣誉与社会职务

1. 中国共产主义青年团第十九次全国代表大会代表

2. 中国青年科技工作者协会第七次会员代表大会代表

3. 海南省“南海新星”项目科技创新人才

4. 海南省人才团队：“衰老与肿瘤创新研究团队”核心成员

5. 中国青年科技工作者协会会员

6. 海南省青年科技工作者协会会员

7. 中国民族医药学会方药量效研究分会常务理事

8. 2019年粤港澳大湾区高价值专利培育布局大赛五十强

研究方向

衰老机制解析与干预策略开发

主要学术成果

期刊论文

1. Jiang Y, Gaur U, Cao Z, Hou S^# & Zheng W^#. Dopamine D1- and D2-like receptors oppositely regulate lifespan via a dietary restriction mechanism in Caenorhabditis elegans. BMC Biology 20, 71 (2022).

2. Jiang Y*, Yan F*, Feng Z, Lazarovici P & Zheng W. Signaling Network of Forkhead Family of Transcription Factors (FOXO) in Dietary Restriction. Cells 9 (2020).

3. Jiang Y*, Rubin L*, Zhou Z, Zhang H, Su Q, Hou S, Lazarovici P & Zheng W. Pharmacological therapies and drug development targeting SARS-CoV-2 infection. Cytokine & Growth Factor Reviews (2022).

4. Jiang Y, Gaur U, Cao Z, Hou S# & Zheng W#. Quetiapine shortens the lifespan of Caenorhabditis elegans through DOP-2, DAF-2 and RSKS-1. International Journal of Molecular Sciences 23(21), 12927 (2022).

5. Jiang Y*, Rubin L*, Peng T, Liu L, Xing X, Lazarovici P & Zheng W. Cytokine storm in COVID-19: from viral infection to immune responses, diagnosis and therapy. International Journal of Biological Sciences 18, 459-472 (2022).

6. Jiang Y*, Peng T*, Gaur U, Silva M, Little P, Chen Z, Qiu W^#, Zhang Y^# & Zheng W^#. Role of Corticotropin Releasing Factor in the Neuroimmune Mechanisms of Depression: Examination of Current Pharmaceutical and Herbal Therapies. Frontiers in Cellular Neuroscience 13, 290 (2019).

7. Peng T*, Jiang Y*, Farhan M, Lazarovici P, Chen L & Zheng W. Anti-inflammatory Effects of Traditional Chinese Medicines on Preclinical in vivo Models of Brain Ischemia-Reperfusion-Injury: Prospects for Neuroprotective Drug Discovery and Therapy. Frontiers in Pharmacology 10, 204 (2019).

8. Li S, Jiang Y, Xing X, Lin R, Li Q, Zhou W, Qiu W & Zheng W. Protective Mechanism of Berberine on Human Retinal Pigment Epithelial Cells against Apoptosis Induced by Hydrogen Peroxide via the Stimulation of Autophagy. Oxidative Medicine and Cellular Longevity 2021 (2021).

9. Zhao X*, Liu L*, Jiang Y, Silva M, Zhen X & Zheng W. Protective Effect of Metformin against Hydrogen Peroxide-Induced Oxidative Damage in Human Retinal Pigment Epithelial (RPE) Cells by Enhancing Autophagy through Activation of AMPK Pathway. Oxidative Medicine and Cellular Longevity 2020, 2524174 (2020).

10. Lin R, Zhou Z, Jiang Y, Liu S, Xie J, Wang H, Ulrich H and Zheng W. Artemisinin exerts antidepressant-like effects via activation of AKT and ERK signaling pathways. Frontiers in Pharmacology. 16:1642167. doi: 10.3389/fphar.2025.1642167 (2025).

11. Zhao X, Huang X, Yang C, Jiang Y, Zhou W & Zheng W. Artemisinin attenuates amyloid-induced brain inflammation and memory impairments by modulating TLR4/NF-κB signaling. International Journal of Molecular Sciences 23, 6354 (2022).

12. Yan F, Wang R, Li S, Zhao X, Jiang Y, Liu L, Fang J, Zhen X, Lazarovici P & Zheng W. FoxO3a suppresses neuropeptide W expression in neuronal cells and in rat hypothalamus and its implication in hypothalamic-pituitary-adrenal (HPA) axis. International Journal of Biological Sciences 16, 2775-2787 (2020).

13. Yan F, Liao R, Silva M, Li S, Jiang Y, Peng T, Lazarovici P & Zheng W. Pristimerin-induced uveal melanoma cell death via inhibiting PI3K/Akt/FoxO3a signalling pathway. Journal of Cellular and Molecular Medicine 24, 6208-6219 (2020).

14. Cui Y, Wang K, Jiang D, Jiang Y, Shi D, DeGregori J, Waxman S & Ren R. Promoting longevity with less cancer: the 2022 International Conference on Aging and Cancer. Aging and Cancer 4:111–120 (2023).

15. Jiang Y and Han J-D J. Lifespan-extending endogenous metabolites. Aging Cell. [Minor Revision]

（* 共同第一作者）

专著章节

Jiang Y & Zheng W. Cell Damage and Transformation in Aging. In: Gu D., Dupre M. (eds) Encyclopedia of Gerontology and Population Aging. Springer, Cham (2019).

科研项目

1. 海南省科学技术厅, 南海新星项目科技创新人才团队项目, 天然产物alterbrassicinol A的合成及抗肿瘤活性研究, 2026-01 至 2028-12, 45万元, 在研, 主持

2. 海南医科大学, 海南医科大学学术提升支撑计划A类项目, RZ2500001786, 阿立哌唑通过调控肠道菌群代谢延缓衰老的机制研究, 2025-01 至 2027-12, 20万元, 在研, 主持

3. 海南医科大学，引进人才科研启动项目, RZ2300005972, 抗衰老代谢物的筛选与机制研究，2023-01-01至2027-12-31，50万元，在研，主持

4. 国家自然科学基金委员会, 面上项目, 32070969, 青蒿素对IGF-1R信号通路的作用和机制，及其在防治阿尔兹海默症的意义, 2021-01-01 至 2024-12-31, 58万元, 结题, 参与