姓名：彭雅南

联系方式：pengyanan2022@muhn.edu.cn

教育及工作经历：

2025-至今      海南医科大学      衰老与肿瘤国际研究中心      PI

2023-2025      海南大学      材料科学与工程学院      博士后

2020-2023      海南医学院      博士（临床检验诊断学）        

2017-2020      海南医学院      基础医学与生命科学学院      教辅

2014-2017      海南医学院      硕士（神经病学）        

2008-2013      海南医学院      学士（临床医学）

研究方向：

DNA纳米技术在生物医药研究中的应用：

●新型DNA纳米结构的设计和开发；

●基于DNA纳米技术的生物检测、细胞成像和药物递送策略；

●DNA纳米技术在衰老与肿瘤相关医学机制研究中的应用。

代表性研究成果：

[1] Yanan Peng ^(#), Qiumei Pu ^(#), Liangqing Lu, Qionglin Zhou, Xinxin Xiao, Xiangde Lai, Xuan Zhao, Bin Qiao, Qiang Wu ^(*). Erasable Fluorescence Imaging Technology Enables Continuous Tracking for Identical Living Cells. Angewandte Chemie International Edition, 2025, e202503818. (IF: 16.1，中科院1区)

[2] Yanan Peng ^(#), Zhijun Gao ^(#), Bin Qiao, Dongxia Li, Huajie Pang, Xiangde Lai, Qiumei Pu, Rui Zhang, Xuan Zhao, Guangyuan Zhao, Dan Xu, Yuanyuan Wang, Yuxiang Ji, Hua Pei, Qiang Wu ^(*). Size-controlled DNA tile self-assembly nanostructures through caveolae-mediated endocytosis for signal-amplified imaging of microRNAs in living cells. Advanced Science, 2023, 2300614. (IF: 14.3，中科院1区)

[3] Yanan Peng ^(#), Huajie Pang ^(#), Zhijun Gao, Dongxia Li, Xiangde Lai, Delun Chen, Rui Zhang, Xuan Zhao, Xinping Chen, Hua Pei, Jinchun Tu, Bin Qiao ^(*), Qiang Wu ^(*). Kinetics-accelerated one-step detection of MicroRNA through spatially localized reactions based on DNA tile self-assembly. Biosensors and Bioelectronics, 2023, 222: 114932. (IF: 10.7，中科院1区)

[4] Yanan Peng ^(#), Dongxia Li ^(#), Zhijun Gao, Qiumei Pu, Huajie Pang, Xiangde Lai, Rui Zhang, Xuan Zhao, Guangyuan Zhao, Dan Xu, Feng Han, Yuanyuan Wang, Yuxiang Ji, Hua Pei, Qiang Wu ^(*). Protonation-mediated DNA tile self-assembly with nuclease resistance characteristic for signal-amplified detection of microRNAs. Biosensors and Bioelectronics, 2024, 246: 115869. (IF: 10.7，中科院1区)

[5] Dongxia Li ^(#), Yanan Peng ^{(#) (*)}, Liangqing Lu ^(#), Delun Chen, Bingrong Wang, Qiumei Pu, Qionglin Zhou, Xinxin Xiao, Mingpeng Fu, Xiaohong Wang, Jinchun Tu ^(*), Hua Pei ^(*), Qiang Wu ^(*). Programmed DNA tile response system enabled accurate detection of ATP for clinical diagnosis. Chemical Engineering Journal, 2024, 499: 156270. (IF: 13.3，中科院1区)

[6] Zhijun Gao ^(#), Qiumei Pu ^(#), Dongxia Li, Rui Zhang, Xiangde Lai, Xuan Zhao, Bin Qiao, Hua Pei, Yanan Peng ^(*), Hua Wang ^(*), Qiang Wu ^(*). One-Step Strand Displacement-Mediated Nucleic Acids Signal-Amplified Analytical Strategy based on Superparamagnetism-Functionalized DNA Arrays. International Journal of Biological Macromolecules. 2025, 308: 142596. (IF: 7.7，中科院2区)

[7] Huajie Pang ^(#), Yanan Peng ^(#), Rui Zhang, Zhijun Gao, Xiangde Lai, Dongxia Li, Xuan Zhao, Yuanyuan Wang, Hua Pei, Bin Qiao ^(*), Yuxiang Ji ^(*), Qiang Wu ^(*). A triggered DNA nanomachine with enzymefree for the rapid detection of telomerase activity in a one-step method, Analytica Chimica Acta. 2024, 1299: 342420. (IF: 5.7，中科院2区)

[8] Qiumei Pu ^(#), Xiangde Lai ^(#), Yanan Peng ^(*), Qiang Wu ^(*). A controllable DNA: structural features and advanced applications of i-motif. Analyst, 2025, 150, 1726-1740. (IF: 3.6，中科院3区)

注：^(#)为第一作者，^(*)为通讯作者。

近年主持的研究项目：

[1] 2025.03-2026.03，海南省自然科学基金青年项目《适体开关定点编程的DNA tile纳米平台在临床体液样本中ATP的信号放大检测》，项目编号：825QN287，6万，主持；

[2] 2024.12-2025.12，海南省博士后研究项目《血糖自驱动的磁性微马达功能化DNA纳米阵列对循环肿瘤细胞的主动诱捕、精准富集新策略》，15万，主持。