杨献文，二级研究员，博导，入选全球前 2% 顶尖科学家“终身科学影响力排行榜”（2025年）及“年度科学影响力排行榜”（2020–2025年）。长期从事海洋天然产物活性成分研究，已构建国际领先的海洋微生物化合物库（CoLMM），先后主持20多项科研项目，包括国家重点研发计划项目课题1项、国家自然科学基金6项；以通讯/第一作者在 Adv. Sci.、J. Med. Chem.、Org. Lett. 等期刊发表 SCI 学术论文120余篇；授权/申请发明专利30项（其中美国专利3项），部分技术成果已实现转化，受到《人民日报》等媒体关注。以第1完成人获自然资源科学技术二等奖、福建省科技进步二等奖等省部级科技进步二等奖4项。
1) Xie, C. L.; Ye, S. H.; Yue, Y. T.; et al. Viridicatol from the deep-sea-derived fungus alleviates bone loss by targeting the Wnt/SHN3 pathway. Adv. Sci. 2025, 12, 2416140.
2) Xie, C. L., Xiao H. X., Song P. F., et al.; Yang, X. W.* Lead optimization of butyrolactone-I as an orally bioavailable antiallergic agent targeting FcγRIIB. J. Med. Chem. 2024, 67, 7504–7515.
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5) Xie, C. L.; Wu, T. Z.; Zhang, D.; et al.; Yang, X. W.* Genome mining of a deep-sea-derived Penicillium allii-sativi revealed unprecedented polyketide–terpenoid hybrids with anti-osteoporosis activity. Org. Lett. 2024, 26, 3889–3895. Supplementary cover.
6) Xie, C. L.; Wu, T. Z.; Zhang, X. K.; et al.; Yang, X. W.* Unveiling the mechanisms of apoptosis induction by deep-sea-derived polyketide–terpenoid hybrids from Penicillium allii-sativi: a focus on mitochondrial and mTOR pathways. Chin. J. Chem. 2024, 42, 3283–3292. Inside cover.
7) Xie, C. L.; Zhang, D.; Guo, K. Q.; et al.; Yang, X. W.* Meroterpenthiazole A, a unique meroterpenoid from the deep-sea-derived Penicillium allii-sativi, significantly inhibited RXR-α transcriptional effect. Chin. Chem. Lett. 2022, 33, 2057–2059.
8) Niu, S.; Xie, C. L.; Xia, J. M.; et al.; Yang, X. W.* Botryotins A–H, tetracyclic diterpenoids representing three carbon skeletons from a deep-sea-derived Botryotinia fuckeliana. Org. Lett. 2020, 22, 580–583.
9) Xie, C. L.; Chen, R.; Yang, S.; et al.; Yang, X. W.* Nesteretal A, a novel class of cage-like polyketide from marine-derived actinomycete Nesterenkonia halobia. Org. Lett. 2019, 21, 8174–8177.
10) He, Z. H.; Xie, C. L.; Wu, T.; et al.; Yang, X. W.* Tetracyclic steroids bearing a bicyclo[4.4.1] ring system as potent anti-osteoporosis agents from the deep-sea-derived fungus Rhizopus sp. W23. J. Nat. Prod. 2023, 86, 157–165.
