个人简介

李孔宁，三级教授、博士生导师、海南省拔尖人才、海南医学院生物信息学专业负责人、热带转化医学教育部重点实验室学术骨干、海南省首批100个人才团队（热带疾病组学大数据创新研究团队）核心成员。 

目前研究方向是复杂疾病多组学数据及生物标志物研究，从事编码RNA和非编码RNA分子的竞争或协同调控作用、多维组学数据整合分析、自噬相关RNA的数据挖掘及其在癌症中的调控作用、生物信息学数据库的构建、生物学网络拓扑分析和癌症分子诊断等方面研究工作。

从事生物信息学、计算机软硬件、仪器仪表、显示驱动与控制等研究30多年。曾留学日本、加拿大10年，并在AMD、ATI等国际知名高科技公司担任高级工程师和项目负责人。主持了国家自然科学基金、省重大科技计划（子课题）、省重点研发、省高层次人才等项目。有10多项科技创新获得了多个国家或地区的专利授权，发表科研论文50多篇。国内第一个“带有无线数传功能的电子钻井参数监控仪表与系统”成果获得国家火炬计划立项推广，多项专利被AMD公司、IGNIS（加拿大）创新技术公司推广应用。出国前曾任中国医学物理学会理事、黑龙江省电子学会理事，现任黑龙江省生物信息学会理事、海南省免疫学会肿瘤免疫专业委员会副主任委员、海南医学院学术委员会委员。

教育经历：

1986.09 - 1989.07, 中国科学院上海技术物理研究所, 半导体物理, 硕士

1982.09 - 1986.07, 黑龙江大学, 理论物理, 学士

科研与学术工作经历：

2018.12 - 至今, 海南医学院, 生物医学信息与工程学院, 教授

2009.6 - 2018.12, 哈尔滨医科大学, 生物信息科学与技术学院, 教授

2006.11 - 2009.06,  IGNIS创新技术公司（加拿大）, 显示控制技术部, 高级工程师

2005.08 - 2006.11, AMD公司（加拿大）, 便携技术研发部, 高级工程师

1999.06 - 2005.08, 凸版技术设计中心（日本）, 显示控制技术部, 数字设计担当

1989.07 - 1999.06, 哈尔滨医科大学, 基础医学院物理教研室, 助教、讲师、副教授

主持或参加科研项目：

1.海南省科技厅，海南省重大科技计划项目，基于临床生物样本大数据的肿瘤患者个体化诊疗体系构建-基于肿瘤生物大数据的肿瘤动态演进及调控机制研究，2021-2024, ZDKJ2021040，分课题主持 

2.国家自然科学基金委员会，地区基金项目，DNA甲基化相关lncRNA在儿童中枢神经系统肿瘤中的免疫调控机制研究，32160152，2022-01至2025-12，主持

3.海南省科技厅，海南省重点研发计划项目，肿瘤FOX家族及其关键基因FOXM1的多组学分子特征研究，ZDYF2021SHFZ097，2021-09至2023-09，主持

4.海南医学院人才科研启动费，2021.5-2026.4，主持

5.海南省科技厅，海南省自然科学基金高层次人才项目，820RC637，基于泛癌失调ceRNA互作网络解析表观调控lncRNA的功能，2020-12至2023-12，主持

6.海南省科技厅，海南省重大科技计划项目，ZDKJ202003，海南省重大传染病关键防控技术研究与应用，2020-12至2023-12，参加

7.国家自然科学基金委员会，青年基金项目，31501075，动态差异DNA甲基化驱动的泛癌风险因子识别及其作用机制研究，2016-01至2018-12，参加（第一）

8.黑龙江省科技厅，黑龙江省自然科学基金重点项目，ZD201114，用于无标记生物电泳检测的薄膜晶体管电荷传感器的研究，2012-01至2014-12，主持

9.黑龙江省教育厅，海外学人项目，1155H012，复杂疾病基因识别系统融合分析方法，2011-01至2013-12，主持

代表性论文：

1.Meng Cao#, Liqiang Wang #, Dahua Xu#, Xiaoman Bi#, Shengnan Guo, Zhizhou Xu, Liyang Chen, Dehua Zheng, Peihu Li, Jiankai Xu, Shaojiang Zheng, Hong Wang, Bo Wang*, Jianping Lu*, Kongning Li*（李孔宁）: The synergistic interaction landscape of chromatin regulators reveals their epigenetic regulation mechanisms across five cancer cell lines, Computational and Structural Biotechnology Journal, 2022.9.12

2.Dahua Xu#, Zhizhou Xu#, Xiaoman Bi#, Meng Cao, Dehua Zheng, Liyang Chen, Peihu Li, Hong Wang, Deng Wu*, Jun Yang*, Kongning Li*（李孔宁）: Identification and functional analysis of N6-methyladenine (m6A)-related lncRNA across 33 cancer types, Cancer Medicine, 2022.6.20

3.Yongsheng Li, Sicong Xu, Dahua Xu, Tao Pan, Guo Jing, Shuo Gu, Qiuyu Lin, Xia Li*, Kongning Li*（李孔宁） and Wei Xiang*：Pediatric pan-central nervous system tumors methylomes analyses reveal immune-related lncRNAs，Frontiers in Immunology，2022.5.4

4.Xiaorong Yu, Jiankai Xu*, Dahua Xu, Xiaoman Bi, Hong Wang, Yanda Lu, Meng Cao, Wenxiang Wang, Zhizhou Xu, Dehua Zheng, Liyang Chen, Xiaodian Zhang, Shaojiang Zheng*, Kongning Li*（李孔宁）：Comprehensive analysis of the carcinogenic process, tumor microenvironment and drug response in HPV-positive cancers，Frontiers in Oncology，2022.3.22

5.Si Li , Weiwei Zhou , Donghao Li, Tao Pan, Jing Guo, Haozhe Zou, Zhanyu Tian, Kongning Li（李孔宁）, Juan Xu*, Xia Li *, Yongsheng Li *：Comprehensive characterization of human-virus protein-protein interactions reveals disease comorbidities and potential antiviral drugs，Computational and Structural Biotechnology Journal, 2022.3.7

6.Shengnan Guo, Tianhao Li, Dahua Xu, Jiankai Xu, Hong Wang, Jian Li, Xiaoman Bi, Meng Cao, Zhizhou Xu, Qianfeng Xia*, Ying Cui*, Kongning Li*（李孔宁）：Prognostic Implications and Immune Infiltration Characteristics of Chromosomal Instability Related Dysregulated CeRNA with Lung Adenocarcinoma，Frontiers in Molecular Biosciences，2022.3.28

7.Ke Xu, Dahua Xu, Hua Pei, Yunfan Quan, Jun Liu, Li Yin, Xuexia Li, ShenTian, Kongning Li *（李孔宁）and Qianfeng Xia*：Whole Blood Transcriptome Analysis Reveals the Correlation between Specific Immune Cells and Septicemic Melioidosis，Disease Markers，2021.10.13

8.Dahua Xu, Shun Ding, Meng Cao, Xiaorong Yu, Hong Wang, Dongqin Qiu, Zhengyang Xu, Xiaoman Bi*, Zhonglin Mu* and Kongning Li*（李孔宁）：A Pan-Cancer Analysis of Cystatin E/M Reveals Its Dual Functional Effects and Positive Regulation of Epithelial Cell in Human Tumors，Frontiers in Genetics，2021.9.17

9.Dahua Xu, Liqiang Wang, Sainan Pang, Meng Cao, Wenxiang Wang, Xiaorong Yu, Zhizhou Xu, Jiankai Xu, Hong Wang*, Jianping Lu* and Kongning Li*（李孔宁）: The functional characterization of epigenetically regulated lncRNAs involved in dysregulated ceRNA-ceRNA networks across 8 cancer types, Frontiers in Cell and Developmental Biology, 2021.6.17 Chunhua Li, Xiaorong Yu, Jianping Lu, Liyu Zheng, Dahua Xu, Zelong Xu, Liqiang Wang, Ying Cui, Yeshuang Li, Hong Wang*, Jiankai Xu*, and Kongning Li*（李孔宁）：Contributions of Gene Modules Regulated by Essential Noncoding RNA in Colon Adenocarcinoma Progression，BioMed Research International, 2020.3.20

10.Chunrui Zhang, Jing Jiang, Liqiang Wang, Liyu Zheng, Jiankai Xu, Xiaolin Qi, Huiying Huang, Jianping Lu*, Kongning Li*（李孔宁） and Hong Wang*：Identification of Autophagy-Associated Biomarkers and Corresponding Regulatory Factors in the Progression of Colorectal Cancer, Frontiers in Genetics, 2020.3.18, 11(245)

11.Kun Qian, Huiying Huang, Jing Jiang, Dahua Xu, Shengnan Guo, Ying Cui, Hao Wang, Liqiang Wang* and Kongning Li*（李孔宁)：Identifying autophagy gene-associated module biomarkers through construction and analysis of autophagy-mediated ceRNA-ceRNA interaction network in colorectal cancer，International Journal of Oncology，2018.6.18，53(3):1083-1093

12.Hong Wang, Dahua Xu, Huiying Huang, Ying Cui, Chunhua Li, Chunrui Zhang, Shengnan Guo, Lining Zhang, Xiaomu Xu, Jiankai Xu, Jianping Lu, Liqiang Wang* and Kongning Li*（李孔宁): Detection of dysregulated competing endogenous RNA modules associated with clear cell kidney carcinoma, Molecular Medicine Reports, 2018.6.19，18(2):1963-1972

13.Ting Zhang, Puwen Tan, Liqiang Wang, Nana Jin, Yana Li, Lin Zhang,Huan Yang, Zhenyu Hu, Lining Zhang, Chunyu Hu, Chunhua Li, Kun Qian, Changjian Zhang, Yan Huang, Kongning Li*（李孔宁), Hao Lin* and Dong Wang*：RNALocate: a resource for RNA subcellular localizations，Nucleic Acids Research, 2016.8.19, D135–D138

14.Yanhui Li, Changliang Wang1, Zhengqiang Miao, Xiaoman Bi, Deng Wu, Nana Jin1, Liqiang Wang, HaoWu, Kun Qian, Chunhua Li, Ting Zhang, Chunrui Zhang, Ying Yi, Hongyan Lai, Yongfei Hu, Lixin Cheng, Kwong-Sak Leung, Xiaobo Li, Fengmin Zhang, Kongning Li*(李孔宁), Xia Li*, and Dong Wang*: ViRBase: a resource for virus–host ncRNA-associated Interactions, Nucleic Acids Research, 2015.1, D578-82

15.Nana Jin，Hao Wu, Zhengqiang Miao, Yan Huang, Yongfei Hu, Xiaoman Bi, Deng Wu,Kun Qian, Liqiang Wang, Changliang Wang, Hongwei Wang, Kongning Li*（李孔宁), Xia Li* & Dong Wang*：Network-based survival-associated module biomarker and its crosstalk with cell death genes in ovarian cancer，Scientific Reports，2015.6.23，5:11566

16.Liqiang Wang, Kun Qian, Yan Huang, Nana Jin, Hongyan Lai, Ting Zhang, Chunhua Li, Chunrui Zhang, Xiaoman Bi, Deng Wu, Changliang Wang, Hao Wu, Puwen Tan, Jianping Lu, Liqun Chen*, Kongning Li*(李孔宁), Xia Li*, and Dong Wang*：SynBioLGDB: a resource for experimentally validated logic gates in synthetic biology，Scientific Reports，2015.1.28, 5:8090

17.Yun Wu, Nana Jin, Haiyang Zhu, Chunmiao Li, Nannan Liu, Yan Huang, Zhengqiang Miao, Xiaoman Bi, Deng Wu, Xi Chen, Yun Xiao, Dapeng Hao, Chuanxing Li, Binsheng Gong, Shaojun Zhang, Liwei Zhuang*, Kongning Li*(李孔宁) and Dong Wang*: Global gene expression distribution in non-cancerous complex diseases, Molecular BioSystems 2014.3.10, 10(4):728-31

18.Xu Jia, Zhengqiang Miao, Wan Li, Liangcai Zhang, Chenchen Feng, Yuehan He, Xiaoman Bi, Liqiang Wang, Youwen Du, Min Hou, Dapeng Hao, Yun Xiao, Lina Chen*, Kongning Li*(李孔宁)：Cancer-risk Module Identification and Module-based Disease Risk Evaluation: A Case Study on Lung Cancer，PLOS ONE, 2014.3.18, 9(3):e92395

19.Nana Jin, Deng Wu, Yonghui Gong, Xiaoman Bi, Hong Jiang, Kongning Li*(李孔宁) and Qianghu Wang*：Integration Strategy Is a Key Step in Network-Based Analysis and Dramatically Affects Network Topological Properties and Inferring Outcomes，BioMed Research International，2014, 2014:296349

20.Kongning Li(李孔宁), Deng Wu, Xi Chen, Ting Zhang, Lu Zhang, Ying Yi, Zhengqiang Miao, Nana Jin, Xiaoman Bi, Hongwei Wang*, Jianzhen Xu*, and DongWang*: Current and Emerging Biomarkers of Cell Death in Human Disease, BioMed Research International, 2014, 2014:690103

获授权知识产权：

1.李孔宁；毕小慢；吴邓；许达华等；Lnc2m6A：癌症N6-甲基腺嘌呤相关lncRNA综合信息平台，2022-5-31,2022SR0677015（软件著作权）

2.李孔宁; 陈宏; 王利强; 吴宇晗; 一种无创双水平呼吸机远程信号调控系统, 201 8-2-2, 中国, ZL201720087071.9. (专利)

3.王凯; 李孔宁; 一种生物大分子荷质比的测量装置及方法, 2016-4-20, 中国, ZL201520863324.8. (专利)

4.李孔宁; 郑晟; 王利强; 苗正强; 王栋; 张绍军; 李霞; 一种便携式体征信号监 测装置, 2014-9-17, 中国, ZL201420033857.9. (专利)

5.李孔宁; 王凯; 夏国杰; 宫滨生; 杜磊; 李霞; 一种电泳成分分析方法和系统, 2 013-4-24, 中国, ZL201010263477.0. (专利)

6.Kongning Li; Gupta Cupertino; Gholamreza Chaji; Arokia Nathan; DRIVING SYSTEM FOR ACTIVE-MATRIX DISPLAYS, 2015-1-20, 美国, US 8,937,632 B2. (专利)

7.G.Eeza Chaji; Kongning Li; Vasudha Gupta; Arokia Nathan; Method and system for driving light emitting display , 2013-6-25, 美国, US 8,471,875 B2. (专利)

8.Kongning Li; Charles Leung; Grigori Temkine; Milivoje Aleksic; Steven ;Turner; Greg Vansickle; Kevin O'Neil Reduced component digital to analog decoder and method , 2011-10-4, 美国, US 8,031,093 B2. (专利)

9.Kongning Li; Vasudha Gupta; G. Reza Chaji; IMPLEMENTATION OF HYBRID DRIVING SCHEME WITH MULTIPLE GAMMA CURVES, 2011-3-9, 加拿大, CA 2678509. (专利)

10.G. Reza Chaji; Kongning Li; Arokia Nathan; IMPROVING THE DISPLAY SOURCE DRIVER, 2010-1-29, 加拿大, CA 2637343. (专利)