个人简历
禹雷,海南医学院生物医学信息与工程学院教辅,哈尔滨医科大学硕士,海南医学院热带转化医学教育部重点实验室热带生物医学组学大数据团队成员,海南医学院计算表观遗传学教研室以及人工智能实验中心成员。
从事研究人类复杂疾病遗传变异分子标记的识别以及功能解析,基于高通量测序技术研究肿瘤中免疫微环境的异质性,耐药性以及免疫细胞和肿瘤细胞的相互作用等。相关研究成果以共同一作发表在Scientific Reports上,参与文章发表在Nucleic acids research,Oncogene,Molecular therapy Nucleic acids上,共发表文章4篇,单篇最高引用74次,总引用131次。参与基金1项。主讲《生物医学数学建模》课程。
科研学习经历:
2015-2019:哈尔滨医科大学-生物医学工程
2019-2022:哈尔滨医科大学-生物医学工程硕士研究生
工作经历:
2022-至今:海南医学院生物医学信息与工程学院
发表文章:
1. Wang Li#, Yu Lei#, Shi Jian#, Li feng#, Zhang Caiyu, Xu Haotian, Yin xiangzhe, Wang lixai, Lin shihua, Anastasiia Litvinova, Ping yanyan*, Ning shangwei* and Zhao Hongying*. Functional regulations between genetic alteration‑driven genes and drug target genes acting as prognostic biomarkers in breast cancer. Scientific Reports. 2022: 10641. (SCI IF:4.996)
2. Zhao Hongying#, Liu Xiaoqin#, Yu Lei, Lin Shihua, Zhang Caiyu, Xu Haotian, Leng Zhijun, Huang Wwaidong, Lei Junjie, Li Tenyue, Li Jing*, Yang Fang* and Wang Li*. Comprehensive landscape of epigenetic-dysregulated lncRNAs reveals a profound role of enhancers in carcinogenesis in BC subtypes. Molecular therapy Nucleic acids. 2021; 23:667-681. (SCI IF:10.183,ESI 高被引论文)
3. Zhao Hongying#, Shi Jian#, Zhang Yunpeng#, Xie Aimin, Yu Lei, Zhang Caiyu, Lei Junjie, Xu Haotian, Leng Zhijun, Li Tengyue, Huang Waidong, Lin Shihua, Wang Li*, Xiao Yun*, Li Xia* . LncTarD: a manually-curated database of experimentally-supported functional lncRNA-target regulations in human diseases. Nucleic acids research, 2020, 48(D1):D118-D126. ( SCI IF:19.160)
4. Li Wang#, Hongying Zhao#, Jing Li#, Yingqi Xu#, Yujia Lan, Wenkang Yin, Xiaoqin Liu, Lei Yu, Shihua Lin, Michael Yifei Du, Xia Li*, Yun Xiao*, Yunpeng Zhang*. Identifying functions and prognostic biomarkers of network motifs marked by diverse chromatin states in human cell lines. Oncogene, 2020,39(3):677-689. (SCI IF:8.756,1 区)
参与基金项目:
1. 黑龙江省普通本科高等学校青年创新人才培养计划(UNPYSCT-2020174), 非编码区遗传变异驱动的癌特异预后标志物识别及信息学平台搭建, 2021-01 至 2024-12,10 万元。(参与)