导师简介
一、个人信息：
梁经纬，教授（高聘），博士，硕士研究生导师。基于人工智能技术，围绕乳腺癌治疗新靶标，开展新药研发工作，以第一作者或通讯作者发表SCI科研论文十余篇，主持国家级项目一项。《中国药物化学杂志》首届青年编委会委员；海南省高层次人才D类；海南医科大学高级人才拔尖层次。
二、教育经历：
2006.9-2011.7 中国医科大学 全日制五年本科 临床药学专业
2012.9-2017.7 中国医科大学药学院 药物化学专业 硕博连读
三、主要工作经历：
2017.7-2020.12 中国医科大学药学院 药物化学教研室 讲师 （期间2018.6-2020.6 中国医科大学临床医学 博士后）
2020.12-2022.12 中国医科大学药学院 药物化学教研室 副教授
2022.12-今 海南医科大学 药学院 药理学教研室 教授（高聘）
四、学术成果：
国家自然基金青年项目-基于卷积神经网络的 CDK2/4双靶点抑制剂动态筛选及抗乳腺癌耐药的构效优化研究（82103998，2022.1-2024.12，主持）
1. Liang J*, Wang M*, Li X, et al. Determination of Structural Requirements of N-Substituted Tetrahydro-β-Carboline Imidazolium Salt Derivatives Using in Silico Approaches for Designing MEK-1 Inhibitors[J]. Molecules, 2017, 22(6): 1-14 中科院3区
2. Liang J*, Li S*, Wang S, et al. Synthesis and biological evaluation of novel (E)-N'-benzylidene hydrazides as novel c-Met inhibitors through fragment based virtual screening[J]. Journal Of Enzyme Inhibition And Medicinal Chemistry, 2020, 35(1): 468-477 中科院2区
3. Liang J*, Wang S*, Wang M, et al. Identification of Novel PI3K delta Selective Inhibitors by SVM-Based Multistage Virtual Screening and Molecular Dynamics Simulations[J]. International Journal Of Molecular Sciences, 2019. 20(23): 6000 中科院2区
4. Liang J*, Li W*, Nian Q, et al. Synthesis and identification of a novel skeleton of N-(pyridin-3-yl) proline as a selective CDK4/6 inhibitor with anti-breast cancer activities. Bioorganic Chemistry, 2022, 119: 105547 中科院1区
5. Wang M*, Liang J*, Olounfeh K, et al. A Comprehensive In Silico Method to Study the QSTR of the Aconitine Alkaloids for Designing Novel Drugs. Molecules 2018, 23(9), 2385 中科院3区
6. Liang J, Li X, He X, et al. (+)- and (-)-itampolin A: first total synthesis, anticancer effect through inhibition of phospho p38 expression. Current Organic Synthesis. 2017, 14(6): 912-917 中科院3区
7. Liang J, Li X, Yang S, et al. Design, Synthesis and Biological Evaluation of Uracil Derivatives as Novel VEGFR-2 Inhibitors[J]. Current Pharmaceutical Design, 2018, 24(6): 734-740. 中科院3区
8. Liang J, Wang M, Wang S, et al. Fragment-Based Structural Optimization of a Natural Product Itampolin A as a p38α Inhibitor for Lung Cancer[J]. Marine Drugs, 2019, 17(1): 53 中科院2区
9. Liang J, Wang M, Olounfeh K, et al. Network pharmacology-based identifcation of potential targets of the flower of Trollius chinensis Bunge acting on anti-inflammatory effects[J]. Scientific Reports, 2019, 9: 8109 中科院3区
10. Liang J, Wang M, Wang S, et al. Identification of novel CDK2 inhibitors by a multistage virtual screening method based on SVM, pharmacophore and docking model[J]. Journal Of Enzyme Inhibition And Medicinal Chemistry, 2020, 35(1): 235-244 中科院2区
11. Yu Y*, Liang J*, Yuan Z, et al. Bioactive compound schaftoside from Clinacanthus nutans attenuates acute liver injury by inhibiting ferroptosis through activation the Nrf2/GPX4 pathway. J Ethnopharmacol. 2024, 28(6): 328:118135. 中科院1区
五、学术组织兼职：
《中国药物化学杂志》首届青年编委会委员
六、联系方式：
jwliang@muhn.edu.cn
