李媛媛简介

一、基本情况：

李媛媛，中共党员，副教授，海南医科大学领军人才，海南省D类人才。2020年博士毕业于南京工业大学制药工程与技术专业，同年入职药学院进行博士后研究工作，2023年加入海南医科大学药学院，长期聚焦于光活性诊疗系统开发，应用于抗肿瘤、抗感染与组织修复等领域。

目前，已在Chem. Eng. J.、J. Control Release 和ACS Appl. Mater. Inter.等国际著名学术期刊发表学术论文17篇，总影响因子超过120，申请发明专利8项，其中5项已授权；主持国家自然科学基金青年基金、海南省自然科学基金青年基金项目、国家卫生健康委员会热带病防治重点实验室开放课题、江苏省高等学校基础科学研究面上项目，参与多项国家级项目和企业转化项目；担任BIO Integration和Exploration期刊的青年编委。

二、主要研究方向：

聚焦光活性诊疗系统开发及其在抗肿瘤、抗感染与组织修复等领域的应用基础研究

三、近五年代表性学术成果

项目经历：

2025.01-至今   

国家自然科学基金青年基金 No. 22408076 主持 高亲和性磷烯基抗菌剂治疗耐药菌生物被膜感染的机制研究

2024.01-至今   

海南省自然科学基金青年基金项目 No. 824QN267 主持 面向耐药菌生物膜感染的多功能固定化溶菌酶的构筑及其性能研究 

2022.06-至今 

江苏省高等学校基础科学研究面上项目 No. 22KJB530006 主持 靶向病原微生物的固定化溶菌酶构筑及其抗耐药菌研究

2021.12-至今

国家重点研发计划 No. 2021YFC2103802 参与者 低廉生物质资源高值化炼制关键技术与产业示范

2021.11-2023.11   

横向项目 合同编号：100803-2021-KY-00090 参与者 养生酒体内功能的药效研究   

论文发表：

[1]Yuanyuan Li, Pengcheng Feng, Cong Wang, Wenjun Miao*, He Huang*, Black phosphorus nanophototherapeutics with enhanced stability and safety for breast cancer treatment, Chemical Engineering Journal, 2020, 400, 125851. (一区, IF: 16.744)

[2]Yuanyuan Li, Jianming Xiong, Wenjing Guo, Yangye Jin, Wenjun Miao*, Cong Wang, Hongman Zhang, Yi Hu*, He Huang*, Decomposable black phosphorus nano-assembly for controlled delivery of cisplatin and inhibition of breast cancer metastasis, Journal of Controlled Release, 2021, 335, 59-74. (一区, IF: 11.467)

[3]Ronglu Zhang#, Yuanyuan Li#, Min Zhou, Cong Wang, Pengcheng Feng, Wenjun Miao*, He Huang*, Photodynamic chitosan nano-assembly as a potent alternative candidate for combating antibiotic-resistant bacteria, ACS Applied Materials & Interfaces, 2019, 11, 26711-26721. (一区, IF: 10.383)

[4]Yuanyuan Li#, Aiyang Tong#, Peiyuan Niu, Wenjing Guo, Yangye Jin, Yi Hu, Pei Tao, Wenjun Miao*, Light-decomposable polymeric micelles with hypoxia-enhanced phototherapeutic efficacy for combating metastatic breast cancer, Pharmaceutics, 2022, 14, 253. (一区, IF: 6.525)

[5]Yuanyuan Li#, Yangye Jin#, Xiaofeng He, Yonghui Tang*, Min Zhou, Wenjing Guo, Wenjun Miao*, Cyclo(RGD) peptide-decorated silver nanoparticles with anti-platelet potential for active platelet-rich thrombus targeting, Nanomedicine: Nanotechnology, Biology, and Medicine, 2022, 41, 102520. (一区, IF: 6.458)

[6]Wenjing Guo#, Yuanyuan Li#, Daoguang An, Min Zhou, Jianming Xiong, Rongrong Huang*, and Wenjun Miao*, Sodium ferulate-functionalized silver nanopyramides with synergistic antithrombotic activity for thromboprophylaxis, Colloids and Surfaces B: Biointerfaces, 2022, 220, 112925. (一区, IF: 5.999)

[7]Yuanyuan Li#, Menghan Wang#, Youtian Tao, Ronglu Zhang, Min Zhou, Pei Tao, Pengcheng Feng, Wei Huang, He Huang*, Wenjun Miao*, Highly stable and biocompatible nanocontrast agent encapsulating a novel organic fluorescent dye for enhanced cellular imaging, Powder Technology, 2019, 358, 110-119. (一区, IF: 5.640)

[8]Yuanyuan Li, Xiaolong Li, Jie Yu, Zheng Wan, Yi Hu, Rongrong Huang, Youtian Tao*, Wenjun Miao*, A versatile diketopyrrolopyrrole-based photosensitizing nanoplatform with high photostability and photoactivity for metastatic breast cancer treatment, Dyes and Pigments, 2022, 207, 110748. (一区, IF: 5.122)

[9]Yuanyuan Li, Jianming Xiong, Yi Hu, Wenjun Miao*, He Huang*, Wrapping collagen‑based nanoparticle with macrophage membrane for treating multidrug‑resistant bacterial infection, Journal of Leather Science and Engineering, 2022, 4, 31. (国产新刊)

[10]Yueying Wang#, Jianming Xiong#, Linwei Xin, Yuanyuan Li*, He Huang*, Wenjun Miao*, Photosensitizer-synergized g-carbon nitride nanosheets with enhanced photocatalytic activity for eradicating drug-resistant bacteria and promoting wound healing, Chinese Chemical Letter, 2024, 110003. (一区, IF: 9.1)

[11]Peiyuan Niu#, Jialing Dai#, Zeyu Wang, Yueying Wang, Duxiang Feng, Yuanyuan Li*, Wenjun Miao*, Sensitization of antibiotic-resistant Gram-negative bacteria to photodynamic therapy via perfluorocarbon nanoemulsion, Pharmaceuticals, 2022, 15, 156. (一区, IF: 5.215)

[12]Jie Yu#, Chenhui Li#, Weipeng Zhang, Yuanyuan Li, Wenjun Miao*, He Huang*, Photodynamic black phosphorus nanosheets functionalized with polymyxin B for targeted ablation of drug-resistant mixed-species biofilms, Journal of Controlled Release, 2024, 372, 795-809. (一区, IF: 11.467)

[13]Yangye Jin, Binbing Zhao, Wenjing Guo, Yuanyuan Li, Juncheng Min, Wenjun Miao*, Penetration and photodynamic ablation of drug-resistant biofilm by cationic iron oxide nanoparticles, Journal of Controlled Release, 2022, 348, 911-923. (一区, IF: 11.467)

[14]Xiaofeng He, Yuxuan Tang, Wenjing Guo, Jianming Xiong, Yuanyuan Li, Rongrong Huang, Wenjun Miao*, Chloroplast–boosted photodynamic therapy for effective drug-resistant bacteria killing and biofilm ablation, Journal of Photochemistry & Photobiology, B: Biology, 2023, 238, 112622. (一区, IF: 6.814)

[15]Yangye Jin#, Cong Wang #, Ziyan Xia, Peiyuan Niu, Yuanyuan Li, Wenjun Miao*, Photodynamic chitosan sponges with dual instant and enduring bactericidal potency for treating skin abscesses, Carbohydrate Polymers, 2023, 306, 120589. (一区, IF: 11.2)

[16]Binbing Zhao, Daoguang An, Yangye Jin, Duxiang Feng, Yueying Wang, Yuanyuan Li, Wenjun Miao*, Mannan-functionalized black phosphorus nanosheets mediate the targeted elimination of intracellular bacteria via combined phototherapy, Journal of Drug Delivery Science and Technology, 2023, 88, 104929. (一区, IF: 4.5)

[17]Wenjing Guo#, Yang Li#, Siyuan Wang, Yueying Wang, Chenhui Li, Yangye Jin, Yuanyuan Li, Xu Chen*, Wenjun Miao*, Photodynamic nano hydroxyapatite with biofilm penetration capability for dental plaque eradication and prevention of demineralization, Colloids and Surfaces B: Biointerfaces, 2023, 225, 113242. (一区, IF: 5.999)

专利申请：

[1]缪文俊, 李媛媛, 郭文靓, 基于阳离子羟基磷灰石的纳米制剂、制备、应用、药物组合物、喷雾剂、漱口水及水凝胶, 2023-06-20, 中国, ZL202210359731.X.

[2]缪文俊, 李媛媛, 郭文靓, 基于纳米羟基磷灰石的递送系统、制备方法、应用、药物组合物、喷雾剂及水凝胶, 2023-05-23, 中国, ZL202210359732.4.

[3]缪文俊, 李媛媛, 牛培元, 医用纳米银递送系统、制备方法、用途、应用及药物组合物, 2022-06-07, 中国, ZL202111121961.4.

[4]张业伟, 李媛媛, 许文景, 一种纳米自组装体及其制备方法与应用, 2022-02-21, 中国, ZL202010923516.9.

[5]黄和, 江凌, 张涛, 田丹碧, 李霜, 林明, 唐飞, 李媛媛, 李燕萍, 一种制备海藻糖晶体的方法, 2012-10-31, 中国, ZL201210431344.9.

[6]缪文俊, 靳洋烨, 赵彬冰, 李媛媛, 基于光敏性纳米复合物的递送系统及其制备方法、应用, 2022-05-10, 中国, CN114887058.A.

[7]黄和, 缪文俊, 李媛媛, 张荣露, 用于光动力抗菌的纳米光敏剂、其制备方法及应用, 2018-5-28, 中国, CN108892743.A.

[8]缪文俊, 黄和, 李媛媛, 周敏佳, 一种近红外光响应性多功能纳米胶束的制备方法及应用, 2018-4-2, 中国, CN108324960.A.   

四、学术组织兼职：

[1]2021年至今  BIO Integration青年编委

[2]2024年至今  Exploration青年编委

五、获得奖励：

[1]2023年  CULSC第八届全国大学生生命科学竞赛（创新创业类）指导教师一等奖   

[2]2022年  南京工业大学本科毕业设计优秀指导老师

六、联系方式： 

liyuanyuan@hainmc.edu.cn