导师简介

一、个人信息：

孔杜林，博士，三级教授，硕士生导师，海南省南海名家，海南省拔尖人才，海南省最美科技工作者，海南省五四青年奖章获得者，海南省首批“双百”人才团队核心成员，海南医科大学青年岗位能手。现任海南医科大学药学院党委副书记兼纪委书记、兼任海南省学位委员会学科评议组成员，海南省化学与材料类教学指导委员会副主任委员，海南省药学会理事，海南省化学化工学会理事，主要从事药物分子设计与合成，主持和参加国家自然科学基金、海南重点科技计划项目、海南省自然科学基金面上项目、海南省高层次人才等多项课题研究工作，在ACS Sustainable Chemistry & Engineering, Organic letters, Bioorganic Chemistry, The Journal of Organic Chemistry等国际权威杂志以第一作者和通讯作者发表SCI收录的学术论文40余篇，申请授权专利3件，主编和参编教材和著作4部。指导学生参加大学生创新创业训练计划项目、挑战杯、互联网+等各类竞赛和社会实践活动多次获国家级和省级奖项。

二、教育经历：

南京理工大学 化学工程 博士研究生 2015.09 至 2019.06

三、主要工作经历：

海南医科大学 药学院党委副书记、纪委书记、教授 2012.02 - 至今

四、学术成果：

以第一作者和通讯作者发表的SCI论文：

（1）孔杜林, 吴明书*, 李倩倩, 马静雅. cis-3-芳脲基-2-苯基-2-氧代萘并[1,2-d]-1,2-氧膦杂环戊烷合成，有机化学，2010, 30(12): 1911-1913

（2）Dulin Kong, Mingshu Wu*, Huiyan Li and Jingya Ma. 9-(1,1-Dimethyl -3-oxobutyl)adenine. Acta Crystallographica Section E, 2010, E66: o2475- o2475

（3）Dulin Kong, Mingshu Wu*, Changri Han, Jingya Ma and Dehui Wan. Synthesis and Characterization of α-aminophosphonic acids Containing Adenine. Asian Journal of Chemistry, 2011, 23(7): 2871-2873

（4）Dulin Kong*, Guozhu Li, Rendie Liu, Synthesis and Crystal Structure of Diethyl Tosyloxybenzylphosphonate. Asian Journal of Chemistry, 2014, 26(7), 2138-2140

（5）Dulin Kong, Rendie Liu, Guozhu Li, Pengwei-Zhang* and Mingshu Wu*. A Rapid Convenient, Solventless Green Approach for the Synthesis of a-Hydroxyphosphonates by Grinding. Asian Journal of Chemistry, 2014, 26(4): 1246-1248

（6）Zhi-Qiang Cai, Xu Hou, Du-Lin Kong*, Ling Hou and Zhi-Quan Hu. Synthesis,crystal structural, and spectral characterisation of dabigatran etexilate tetrahydrate. Journal of Chemical Research, 2016, 40(8): 461-466

（7）Dulin Kong, Jie Jiang, Luyong Wu, Xianghui Wang, Zaifeng Shi, Mingshu Wu, Xin Wang*, Qiang Lin*. Synthesis, Structure and Antimicrobial Activity of 9,9-Dimethyl-9,10-dihydrospiro [benzo[a]- xanthene-12,3΄-indoline]-2΄,11(8H)- dione. Chinese Journal of Structural Chemistry, 2016, 35(12): 1849-1854

（8）Dulin Kong, Xianghui Wang, Zaifeng Shi, Mingshu Wu, Qiang Lin* and Xin Wang. Solvent- and catalyst-free synthesis of imidazo[1,2-a]pyridines under microwave irradiation. Journal of Chemical Research, 2016, 40(9): 529-531

（9）Dulin Kong, Jie Jiang, Qinghe Wang, Zhongxiang Zhu, Xianghui Wang, Luyong Wu, Zaifeng Shi, Mingshu Wu*, Qiang Lin*. Synthesis, Structure and Antimicrobial Activity of 2΄-Thioxo-2΄,3΄-dihydro-1΄H,2H- spiro[naphtho[2,1-b]furan-1,5΄-pyrimido- [4,5-b]quinoline]-2,4΄(10΄H)-dione.Chinese Journal of Structural Chemistry, 2017, 36(5): 781-785

（10）Dulin Kong, Zhongxiang Zhu, Jie Jiang, Luyong Wu, Xianghui Wang, Zaifeng Shi, Qiang Lin*, and Mingshu Wu*. A One-Pot, Green Synthesis of Betti Base Containing Adenine Derivatives in Aqueous Medium. Heterocycles, 2017, 94(2): 297-307

（11）Dulin Kong, Qinghe Wang, Zhongxiang Zhu, Xianghui Wang, Zaifeng Shi, Qiang Lin*, Mingshu Wu*. Convenient one-pot synthesis of thiobarbituro-quinoline derivatives via catalyst-free multicomponent reactions in water. Tetrahedron Letters, 2017, 58(27): 2644-2647

（12）Du-lin Kong, Guo-ping Lu*, Ming-shu Wu, Zai-feng Shi, and Qiang Lin*. One-Pot, Catalyst-Free Synthesis of Spiro[dihydroquinoline naphthofuranone] Compounds from Isatins in Water Triggered by Hydrogen Bonding Effects. ACS Sustainable Chemistry & Engineering, 2017, 5 (4): 3465–3470

（13）Dulin Kong, Qinghe Wang, Tiao Huang, Min Liang, Qiang Lin*, Mingshu Wu*. Metal-free direct regioselective thiolation of imidazoheterocycles in water at room temperature. Tetrahedron, 2019, 75(10): 1457-1463

（14）Dulin Kong, Tiao Huang, Min Liang, Mingshu Wu* and Qiang Lin*. KIO3-catalyzed cross dehydrogenative coupling reaction: sulfenylation of phenol and arylamine derivatives in water at room temperature. Organic & Biomolecular Chemistry, 2019,17(4): 830-834

（15）Xun Chen,* Xue Cui, Lili Bai, Ying Wang, Ying Xie,* Shuojin Wang, Ruirui Zhai, Ke Zhao, Dulin Kong*, and Youbin Li*.Ruthenium(II)-Catalyzed C-H Bond [3+2] Annulation of N-Nitrosoanilines with Alkynes in Water. Asian Journal of Organic Chemistry, 2019, 8(12): 2209-2212

（16）Tiao Huang, Li Liu, Qinghe Wang, Dulin Kong*, Mingshu Wu*, 1,3-Dipolar Cycloaddition of 3-Amino Oxindole-Based Azomethine Ylides and O-Vinylphosphonylated Salicylaldehydes for Diastereoselective Synthesis of Oxindole Spiro-P,N-polycyclic Heterocycles. Synthesis, 2020, 52(09): 1387-1397

（17）Tiao Huang, Li Liu, Qinghe Wang, Dulin Kong*, Mingshu Wu*, P(OEt)3 -Mediated Formal S–H Insertion: Reductive Couplings of Isatins with Thiols to Generate 3-Sulfenylated Oxindoles. Synthesis, 2020, 52: 2689-2697

（18）Li Liu, Yue Li, Tiao Huang, Dulin Kong* and Mingshu Wu*,A novel methodology for the efficient synthesis of 3-monohalooxindoles by acidolysis of 3-phosphate-substituted oxindoles with haloid acids. Beilstein The Journal of Organic Chemistry. 2021, 17, 2321-2328

（19）Li Liu, Yue Li, Feng Wang, Rui Ning, Dulin Kong* and Mingshu Wu*, A new synthetic approach to oxindoles (1,3-dihydro-2H-indol-2-ones) by reductive dephosphorylation with hydroiodic acid of 3-(diethylphosphoryloxy)-oxindoles, derived from isatins (1H-Indole-2,3-diones). Arkivoc 2022, v, 135-146

（20）Xiao-lin Cui, Hao-yu Tian, Shuo-jin Wang, Xun Chen*, Du-lin Kong*, KBrO3-Promoted Cross-Dehydrogenative Coupling Reaction: An Odorless Regioselective Sulfenylation of Imidazoheterocycles in Water. The Journal of Organic Chemistry, 2023 88 (13), 8576-8582

（21）Jianzhang Wu*, Xin Liu , Jie Zhang , Jiali Yao , Xiaolin Cui, Yaling Tang , Zixuan X, Meiting Han , Haoyu Tia, Yan Chen, Qiyun Fan , Wulan Li*, Dulin Kong*, Green synthesis and anti-tumor efficacy via inducing pyroptosis of novel 1H-benzo[e]indole-2(3H)-one spirocyclic derivatives, Bioorganic Chemistry Pub Date : 2023-10-21 , 2024, 142, 106930

（22）Xiaoyang Gao, Juting Liao, Hengyi Wei, Ye Xu, Ruirui Zhai, Dulin Kong*, Shuojin Wang*, Xun Chen*,TEMPO-Mediated Dehydrogenative Hydroxyfluoroalkylation of Arylamines with Polyfluorinated Alcohols. The Journal of Organic Chemistry, 2024, 89, 6169 - 6179

（23）Haoyu Tian, Qinghe Wang, Wenyan Wei, Yan Chen, Xia Zhong, Guiwei Yao, Xun Chen*, Guangkuan Zhao*, Dulin Kong*. Synthesis of α-Carbonyl-α'-sulfenyl Sulfoxonium Ylides in Water at Room Temperature. The Journal of Organic Chemistry. 2024;89(21):15523-15528.

（24）Juting Liao, Ruirui Zhai, Xiaoyang Gao, Hongliang Wu, Dulin Kong*, Shuojin Wang*, Xun Chen*,Rh(III)‐Catalyzed C‐H Cyclization of 2‐Arylbenzimidazoles with CF3‐Imidoyl Sulfoxonium Ylides and Further Sc(III)‐Catalyzed Deaminative Hydroxylation.Advanced Synthesis & Catalysis, Pub Date : 2024-11-16, DOI:10.1002/adsc.202401220.

（25）Xiaoyang Gao, Ruirui Zhai, Juting Liao, Guiwei Yao, Hui Meng, Yuchao, Luo, Dulin Kong*, Shuojin Wang*, Xun Chen*, Condition-Controlled Rh(III)-Catalyzed Chemodivergent Cyclization of 2-Arylpyridines with CF3-Imidoyl Sulfoxonium Ylides via Triple C-H Activation. Organic letters, DOI:10.1021/acs.orglett.4c04514.

著作：

1．孔杜林(合著，本人撰写约10万字).《染料生产技术》.北京:科学出版社,2014.4

2．孔杜林(合著，本人撰写约12.1万字). 《精细有机中间体生产技术》.北京:科学出版社,2016.4

近年来主持课题：

（1）海南省自然科学基金面上项目(20162033)：6（9）-位取代新型嘌呤开环核苷类化合物的合成及抗病毒活性研究2016-01至2018-12，8万元，主持。

（2）海南省自然科学基金高层次人才项目(2019RC215)：基于水介质中多组分反应构筑吲哚类抗肿瘤小分子化合物的研究，2020-01至2022-12，10万元，主持。

（3）海南省水环境污染治理与资源化重点实验室课题：水介质中构建靛红螺环化合物的研究，2017-09至2020-09，3万元，主持。

（4）海南医学院引进人才科研启动费(XRC200013), 25万元，主持。

五、学术组织兼职：

海南省学位委员会学科评议组成员，海南省化学与材料类教学指导委员会副主任委员，海南省药学会理事，海南省化学化工学会理事

六、获得奖励：

2018年在《结构化学》举办的“优秀论文”评选活动，荣获优秀奖。

2019年入选海南省南海名家青年项目，海南省拔尖人才。

2019年荣获海南医学院“青年岗位能手”称号。

2020年入选海南省首批“双百”人才团队核心成员。

2021年荣获海南省五四青年奖章。

2022年荣获海南省最美科技工作者。

七、联系方式： 

kongdulin@muhn.edu.cn