许达华

        许达华，海南医科大学生物医学信息与工程学院、生物医药健康大数据中心讲师。担任海南省医学会数字医学分会委员，海南省免疫学会青年工作专业委员会委员，入选海南自由贸易港高层次人才。主要研究方向为复杂疾病的生物信息学研究，围绕非编码元件的表观遗传调控机制、ceRNA调控网络、泛癌关键基因及基因家族、人类长寿机制、病毒感染以及新型疾病诊断治疗靶点识别等多方向展开研究，系列成果在《Theranostics》，《Aging Cell》，《Infectious Diseases of Poverty》等杂志发表SCI论文 24篇，其中以第一和共一作者身份发表SCI论文21篇，受邀担任Briefing in Bioinformatics、Biomarker Research、Experimental Hematology & Oncolog等十余本国际著名学术杂志审稿专家。相关成果已申请国家发明专利三项，授权软件著作权五项。。目前主持海南省级基金3项，参与国家自然科学基金、海南省重大、重点研发项目、高层次人才等项目9项。指导学生获国赛三等奖、省赛三等奖等。主讲《计算表观遗传学》、《生物网络分析》、《生物医学信息学前沿进展》等多门生物信息学本、硕、博专业课程。

发表论文：

1)Dahua Xu^#（许达华）, Meng Cao^#, Bo Wang ^#, Xiaoman Bi^#, Haiying Zhang, Deng Wu, Chunrui Zhang, Jiankai Xu, Zhizhou Xu, Dehua Zheng, Liyang Chen, Peihu Li, Hong Wang, Yan Liu^*, Hongyan Jiang^*, Kongning Li^*：Epigenetically regulated lncRNAs dissect the intratumoural heterogeneity and facilitate immune evasion of glioblastomas. Theranostics. 2023 Mar 5;13(5):1490-1505. (SCI)

2)Guanghui Tian^#, Dehua Zheng^#, Nihui Zhang^#, Wanxin Deng, Jiankai Xu, Chenqing Huang, Qiang Chen, Shasha Hu, Li Xin, Hong Wang, Bo Wang*, Kongning Li*, Dahua Xu*（许达华）：Association of blood-based DNA methylation of lncRNAs with Alzheimer's disease diagnosis. Clinical Epigenetics. 2025. (SCI)

3)Dahua Xu^#（许达华）, Yutong Shen^#, Nihui Zhang^#, Guoqing Deng^#, Dehua Zheng, Peihu Li, Jiale Cai, Guanghui Tian, Qingchen Wei, Hongyan Jiang, Jiankai Xu^*, Bo Wang^*, Kongning Li^*：Aging2Cancer: an integrated resource for linking aging to tumor multi-omics data. BMC Genomics, Dec 18;25(1):1205. (SCI)

4)Dahua Xu^#（许达华）, Chunrui Zhang^#, Xiaoman Bi^#, Jiankai Xu, Shengnan Guo, Peihu Li, Meng Cao, Zhizhou Xu, Dehua Zheng, Liyang Chen, Hong Wang, Qifu Li, Hongyan Jiang, Bo Wang^*, Xia Li^*, Yongsheng Li^*, Kongning Li^*: Mapping enhancer and chromatin accessibility landscapes charts the regulatory network of Alzheimer disease. Computers in Biology and Medicine. 2024 Jan:168:107802. (SCI)

5)Dahua Xu^#（许达华）, Nihui Zhang^#, Yutong Shen^#, Dehua Zheng^#, Zhizhou Xu, Peihu Li, Jiale Cai, Guanghui Tian, Qingchen Wei, Hong Wang, Hongyan Jiang, Meng Cao^*, Bo Wang^*, Kongning Li^*：Single-cell sequencing analysis reveals the dynamic tumour ecosystems of primary and metastatic lymph nodes in nasopharyngeal carcinoma. Journal of Cellular and Molecular Medicine. 2024 Oct 28 (19), e70137.(SCI)

6)Dahua Xu^#（许达华）, Liqiang Wang^#, Sainan Pang^#, Meng Cao, Wenxiang Wang, Xiaorong Yu, Zhizhou Xu, Jiankai Xu, Hong Wang*, Jianping Lu* and Kongning Li*: The functional characterization of epigenetically regulated lncRNAs involved in dysregulated ceRNA-ceRNA networks across 8 cancer types. Frontiers in Cell and Developmental Biology. 2021 Jun 17:9:649755. (SCI)

7)Dahua Xu^#（许达华）, Zhizhou Xu^#, Xiaoman Bi^#, Meng Cao, Dehua Zheng, Liyang Chen, Peihu Li, Hong Wang, Deng Wu^*, Jun Yang^*, Kongning Li*: Identification and functional analysis of N6-methyladenine (m6A)-related lncRNA across 33 cancer types. Cancer Medicine. 2023 Jan;12(2):2104-2116. (SCI)

8)Dahua Xu^#（许达华）, Peihu Li^#, Chunrui Zhang^#, Yutong Shen, Jiale Cai, Qingchen Wei, Meng Cao, Zhizhou Xu, Deng Wu, Hong Wang, Xiaoman Bi^*, Bo Wang^*, Kongning Li^*. Development of an m6A-related lncRNAs signature predicts tumor stemness and prognosis for low-grade glioma patients. Stem Cells International. 2024 Jan. (SCI)

9)Dahua Xu^#（许达华）, Shun Ding^#, Meng Cao^#, Xiaorong Yu, Hong Wang, Dongqin Qiu, Zhengyang Xu, Xiaoman Bi*, Zhonglin Mu* and Kongning Li*：A Pan-Cancer Analysis of Cystatin E/M Reveals Its Dual Functional Effects and Positive Regulation of Epithelial Cell in Human Tumors. Frontiers in Genetics. 2021 Sep 17:12:733211. (SCI)

10)Minyu Zhou^#, Lian Xu^#, Dahua Xu^#（许达华）, Wen Chen^#, Jehangir Khan, Yue Hu, Hui Huang, Hang Wei, Yiqing Zhang, Phiraphol Chusongsang, Kanthi Tanasarnprasert, Xiang Hu*, Yanin Limpanont*, Zhiyue Lv*: Chromosome‑scale genome of the human blood fluke Schistosoma mekongi and its implications for public health. Infectious Diseases of Poverty. 2023 Nov 28;12(1):104. (SCI)

11)Peihu Li^#, Xiaoman Bi^#, Dahua Xu^#（许达华）, Yuan Meng^#, Yucheng Xia, Jiale Cai, Yutong Shen, Jiaqi Wang, Jiazhu Chen, Lamei Yin, Bo Wang*, Deng Wu*, Kongning Li*: Activation of the hypoxia response in the aging cerebrovasculature protects males against cognitive impairment. Aging Cell. 2024 Jun 21; e14264 (SCI)

12)Jiayao Chen^#, Dahua Xu^#（许达华）, Bocen Chen^#, Shaoqin Jian, Tong Chen, Wenguang Wang, Yingjie Ma, Jing Zhang, Kongning Li*, Wangwei Cai*, Man Xiao*: Senescent macrophages trigger a pro-inflammatory program and promote the progression of rheumatoid arthritis. International Immunopharmacology. 2025 Mar 6:149:114164. (SCI)

13)Jiale Cai^#, Deng Wu^#, Dahua Xu^#（许达华）, Fujin Liu, Peihu Li, Dehua Zheng, Zhizhou Xu, Meng Cao, Yutong Shen, Nihui Zhang, Guanghui Tian, Chengyi Fan, Bo Wang*, Kongning Li*, Xiaoman Bi*: Integrative Transcriptomic Analysis Decodes the Interplay Between Aging, Senescence, and Cancer. Cancer Science. 2025 Nov;116(11):3066-3078. (SCI)

14)Xiaoman Bi^#, Dehua Zheng^#, Jiale Cai^#, Dahua Xu^#（许达华）, Liyang Chen, Zhizhou Xu, Meng Cao, Peihu Li, Yutong Shen, Hong Wang, Wuping Zheng, Deng Wu^*, Shaojiang Zheng^*, Kongning Li^*, Pan-cancer analyses reveal multi-omic signatures and clinical implementations of the forkhead-box gene family. Cancer Medicine. 2023 Aug;12(16):17428-17444. (SCI)

15)Xiaoman Bi^#, Liyang Chen^#, Deng Wu^#, Dahua Xu^#（许达华）, Dehua Zheng, Zhizhou Xu, Zhenling Wan, Shaoping Zheng^*, Kongning Li^*, Shaojiang Zheng^*: The molecular and immune landscape of the forkhead-box gene family in different subtypes of breast cancer. Genes & Diseases. 2025 October 29, 101911. (SCI)

16)Yongsheng Li^#, Sicong Xu^#, Dahua Xu^#（许达华）, Tao Pan, Guo Jing, Shuo Gu, Qiuyu Lin, Xia Li*, Kongning Li* and Wei Xiang*：Pediatric pan-central nervous system tumors methylomes analyses reveal immune-related lncRNAs. Frontiers in Immunology. 2022 May 4:13:853904. (SCI)

17)Meng Cao^#, Liqiang Wang ^#, Dahua Xu^#（许达华）, Xiaoman Bi^#, Shengnan Guo, Zhizhou Xu, Liyang Chen, Dehua Zheng, Peihu Li, Jiankai Xu, Shaojiang Zheng, Hong Wang, Bo Wang*, Jianping Lu*, Kongning Li*: The synergistic interaction landscape of chromatin regulators reveals their epigenetic regulation mechanisms across five cancer cell lines. Computational and Structural Biotechnology Journal. 2022 Sep 12:20:5028-5039. (SCI)

18)Xiaorong Yu^#, Jiankai Xu^#*, Dahua Xu^#（许达华）, Xiaoman Bi, Hong Wang, Yanda Lu, Meng Cao, Wenxiang Wang, Zhizhou Xu, Dehua Zheng, Liyang Chen, Xiaodian Zhang, Shaojiang Zheng*, Kongning Li*：Comprehensive analysis of the carcinogenic process, tumor microenvironment and drug response in HPV-positive cancers. Frontiers in Oncology. 2022 Mar 22:12:842060. (SCI)

19)Shengnan Guo^#, Tianhao Li^#, Dahua Xu^#（许达华）, Jiankai Xu, Hong Wang, Jian Li, Xiaoman Bi, Meng Cao, Zhizhou Xu, Qianfeng Xia*, Ying Cui*, Kongning Li*：Prognostic Implications and Immune Infiltration Characteristics of Chromosomal Instability Related Dysregulated CeRNA with Lung Adenocarcinoma. Frontiers in Molecular Biosciences. 2022 Mar 28:9:843640. (SCI)

20)Hong Wang^#, Dahua Xu^#（许达华）, Huiying Huang^#, Ying Cui, Chunhua Li, Chunrui Zhang, Shengnan Guo, Lining Zhang, Xiaomu Xu, Jiankai Xu, Jianping Lu, Liqiang Wang* and Kongning Li*: Detection of dysregulated competing endogenous RNA modules associated with clear cell kidney carcinoma. Molecular Medicine Reports. 2018 Aug;18(2):1963-1972. (SCI)

21)Ke Xu^#, Dahua Xu^#（许达华）, Hua Pei, Yunfan Quan, Jun Liu, Li Yin, Xuexia Li, ShenTian, Kongning Li* and Qianfeng Xia*：Whole Blood Transcriptome Analysis Reveals the Correlation between Specific Immune Cells and Septicemic Melioidosis. Disease Markers. 2021 Oct 13:2021:6166492. (SCI)

22)Kun Qian, Huiying Huang, Jing Jiang, Dahua Xu（许达华）, Shengnan Guo, Ying Cui, Hao Wang, Liqiang Wang* and Kongning Li*：Identifying autophagy gene-associated module biomarkers through construction and analysis of autophagy-mediated ceRNA-ceRNA interaction network in colorectal cancer. International Journal of Oncology. 2018 Sep;53(3):1083-1093. (SCI)

23)Chunhua Li, Xiaorong Yu, Jianping Lu, Liyu Zheng, Dahua Xu（许达华）, Zelong Xu, Liqiang Wang, Ying Cui, Yeshuang Li, Hong Wang*, Jiankai Xu*, and Kongning Li*：Contributions of Gene Modules Regulated by Essential Noncoding RNA in Colon Adenocarcinoma Progression. BioMed Research International. 2020 Mar 20:2020:8595473. (SCI)

24)Deng Wu, Xiaoman Bi, Peihu Li, Dahua Xu（许达华）, Jianmin Qiu, Kongning Li, Shaojiang Zheng, Kim Hei-Man Chow: Enhanced insulin-regulated innate monocyte phagocytic activities support extreme health span and longevity in multiple populations. Aging Cell. 2023 May;22(5):e13810. (SCI)

数字化教学资源

1)软件著作权：Lnc2m6A: 癌症N6-甲基腺嘌呤相关lncRNA综合信息平台，李孔宁、毕小慢、吴邓、许达华、徐智洲、曹勐，著作权号：2022SR0677015

2)软件著作权：癌症相关FOX基因家族多组学综合信息平台，毕小慢、李孔宁、蔡佳乐、郑德华、许达华，著作权号：2023SR1200009

3)软件著作权：Aging2Cancer：解析衰老与肿瘤多维组学特征的一站式分析平台，许达华、李孔宁、申雨桐、蔡家乐，著作权号：2024SR0377198。

4)软件著作权：EasyMeth: DNA甲基化一站式分析平台，许达华、李孔宁、侯灯磊、蔡佳乐、申雨桐，著作权号：2024SR0386112。

5)软件著作权：iGTExAging：一站式识别GTEx衰老基因软件, 李孔宁、李佩虎、毕小慢、许达华，著作权号：2024SR0643265

6)上线平台：Aging2Cancer：http://210.37.77.200:8080/Aging2Cancer/

7)上线平台：Lnc2m6A： http://hainmu-biobigdata.com/Lnc2m6A/index.php

8)上线平台：FOX2Cancer: http://hainmu-biobigdata.com/FOX2Cancer/

主要获奖

1)2022年获得博士研究生国家奖学金

2)2021年获得国际肿瘤精准医学高峰论坛会议杰出研究奖

3)2023年获得Wiley威立中国开放科学高贡献作者

4)2023年指导学生获得海峡两岸暨港澳地区大学生计算机创新作品赛三等奖

5)2024年指导学生获得第九届全国大学生生物医学工程创新设计竞赛三等奖

6)2025年指导学生获得全国医科院校研究生院联盟2025年研究生论坛论文三等奖

7)2025年指导学生获得全国医科院校研究生院联盟2025年研究生论坛壁报优胜奖

8)2025年指导学生获得中国国际大学生创新大赛校级三等奖