Fundamentals and developments in  fluorescence- guided cancer surgery

荧光引导癌症手术的基础和发展

主讲人：张俊

Nat Rev Clin Oncol 19, 9–22 (2022). https://doi.org/10.1038/s41571-021-00548-3

ABSTRACT:

        Fluorescence- guided surgery using tumour- targeted imaging agents has emerged  over the past decade as a promising and effective method of intraoperative cancer detection. An impressive number of fluorescently labelled antibodies, peptides, particles and other molecules  related to cancer hallmarks have been developed for the illumination of target lesions. New  approaches are being implemented to translate these imaging agents into the clinic, although  only a few have made it past early- phase clinical trials. For this translational process to succeed,  target selection, imaging agents and their related detection systems and clinical implementation  have to operate in perfect harmony to enable real- time intraoperative visualization that can  benefit patients. Herein, we review key aspects of this imaging cascade and focus on imaging  approaches and methods that have helped to shed new light onto the field of intraoperative  fluorescence- guided cancer surgery with the singular goal of improving patient outcomes.

摘要：

   肿瘤靶向显像剂的荧光引导手术是近十年来出现的一种有前途和有效的术中肿瘤检测方法。大量的荧光标记抗体、多肽、粒子和其他与癌症特征相关的分子已经被开发出来，用于靶病变的显像。新的方法正在实施，将这些显像剂转化为临床，尽管只有少数通过了早期临床试验。为了使这一转化过程取得成功，目标选择、显像剂及其相关检测系统和临床实施必须完美协调，以实现术中实时可视化，从而使患者受益。在此，我们回顾了这种成像级联的关键方面，并重点介绍了成像方式和方法，这些方式和方法有助于为术中荧光引导癌症手术领域提供新的视角，以改善患者的预后。