Towards Reliable and Quantitative Surface-Enhanced Raman Scattering (SERS): From Key Parameters to Good Analytical Practice

迈向可靠且定量的表面增强拉曼散射 (SERS)：从关键参数到良好的分析实践

主讲人：王安慧

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION（IF:16.6）:2020-02-20,1908154

https://doi.org/10.1002/anie.201908154

Abstract：

        Experimental results obtained in different laboratories world-wide by researchers using surface-enhanced Raman scattering (SERS) can differ significantly. We, an international team of scientists with longstanding expertise in SERS, address this issue from our perspective by presenting considerations on reliable and quantitative SERS. The central idea of this joint effort is to highlight key parameters and pitfalls that are often encountered in the literature. To that end, we provide here a series of recommendations on: a) the characterization of solid and colloidal SERS substrates by correlative electron and optical microscopy and spectroscopy, b) on the determination of the SERS enhancement factor (EF), including suitable Raman reporter/ probe molecules, and finally on c) good analytical practice. We hope that both newcomers and specialists will benefit from these recommendations to increase the inter-laboratory comparability of experimental SERS results and further establish SERS as an analytical tool.      

摘要：

   研究人员使用表面增强拉曼散射 (SERS) 在世界各地不同实验室获得的实验结果可能存在显着差异。我们是一个由长期从事 SERS 研究的科学家组成的国际团队，从我们的角度出发，提出了有关可靠和定量 SERS 的考虑因素，从而解决了这一问题。这个共同努力的中心思想是强调在文献中经常遇到的关键参数和陷阱。为此，我们在此提供了一系列建议:a)通过相关电子和光学显微镜和光谱学表征固体和胶体SERS基底，b) SERS增强因子(EF)的确定，包括合适的拉曼报告/探针分子，最后是c)在实际应用中有一个良好的分析结果。我们希望新手和专家都能从这些建议中受益，以提高实验 SERS 结果的实验室间可比性，并进一步将 SERS 确立为一种分析工具。