Silver@Prussian Blue Core−Satellite Nanostructures as Multimetal Ions Switch for Potent Zero-Background SERS Bioimaging-Guided Chronic Wound Healing

银@普鲁士蓝核心-卫星纳米结构作为多金属离子开关，用于有效的零背景SERS生物成像引导慢性伤口愈合

主讲人：邓晗彬

Nano Lett. 2023, 23, 18, 8761–8769

https://doi-org.ezproxy.is.ed.ac.uk/10.1021/acs.nanolett.3c02857

Abstract:

           Metal−organic framework-based metal ion therapy has attracted increasing attention to promote the cascade wound-healing process. However, multimetal ion synergistic administration and accurately controlled ion release are still the challenges. Herein, an aptamer-functionalized silver@cupriferous Prussian blue (ACPA) is established as a metal-based theranostic nanoagent for a chronic nonhealing diabetic wound treatment. Prussian blue offers a programmable nanoplatform to formulate metal ion prescriptions, achieving cooperative wound healing. Silver, copper, and iron ions are released from ACPA controlled by the near-infrared-triggered mild hyperthermia and then synergistically participate in antipathogen, cell migration, and revascularization. ACPA also demonstrates a unique core−satellite nanostructure which enables it with improved surfaceenhanced Raman scattering (SERS) capability as potent bacteria-targeted Ramansilent nanoprobe to monitor the residual bacteria during wound healing with nearly zero background. The theranostic feature of ACPA allows highperformance SERS imaging-guided chronic wound healing in infectious diabetic skin and keratitis.

摘要：

基于金属-有机框架的金属离子治疗在促进级联伤口愈合过程中受到越来越多的关注。然而，多金属离子协同给药和精确控制离子释放仍然是一个挑战。在此，一种适配体功能化银@普鲁士蓝(ACPA)被建立为一种金属基治疗纳米剂，用于慢性不愈合的糖尿病伤口治疗。普鲁士蓝提供了一个可编程的纳米平台来制定金属离子处方，实现伤口的协同愈合。银、铜和铁离子由近红外触发的轻度热疗控制从ACPA释放，然后协同参与抗病原体、细胞迁移和血运重建。ACPA还展示了一种独特的核心-卫星纳米结构，使其具有改进的表面增强拉曼散射(SERS)能力，作为有效的细菌靶向拉曼沉默纳米探针，可以在接近零背景的情况下监测伤口愈合过程中的残留细菌。ACPA的治疗特点允许高性能SERS成像引导慢性伤口愈合感染性糖尿病皮肤和角膜炎。