Multifunctional Janus Nanoplatform for Efficiently Synergistic Theranostics of Rheumatoid Arthritis

多功能Janus纳米平台，高效协同治疗类风湿性关节炎

主讲人：曹秀红

ACS Nano 2023, 17, 8167−8182

https://pubs.acs.org/doi/full/10.1021/acsnano.2c11777

Abstract:   

        Progress has been made in the application of nanomedicine in rheumatoid arthritis (RA) treatment. However, the whole process of monitoring and treatment of RA remains a formidable challenge due to the complexity of the chronic autoimmune disease. In this study, we develop a Janus nanoplatform (denoted as Janus-CPS) composed of CeO2−Pt nanozyme subunit on one side and periodic mesoporous organosilica (PMO) subunit on another side for simultaneous early diagnosis and synergistic therapy of RA. The Janus nanostructure, which enables more active sites to be exposed,enhances the reactive oxygen species scavenging capability of CeO2−Pt nanozyme subunit as compared to their core−shell counterpart. Furthermore, micheliolide (MCL), an extracted compound from natural plants with anti-osteoclastogenesis effects, is loaded into the mesopores of PMO subunit to synergize with the anti-inflammation effect of nanozymes for efficient RA treatment, which has been demonstrated by in vitro cellular experiments and in vivo collagen-induced arthritis (CIA) model. In addition, by taking advantage of the second near-infrared window (NIR-II) fluorescent imaging, indocyanine green (ICG)-loaded Janus-CPS exhibits desirable effectiveness in detecting RA lesions at a very early stage. It is anticipated that such a Janus nanoplatform may offer an alternative strategy of functional integration for versatile theranostics.

摘要：

 纳米药物在类风湿性关节炎（RA）治疗中的应用已经取得了研究进展然而，由于慢性自身免疫性疾病的复杂性，RA的监测和治疗的整个过程仍然是一个艰巨的挑战。在本研究中，我们开发了一个Janus纳米平台（Janus-CPS），一侧由ceo2−Pt纳米酶亚基组成，另一侧由周期性介孔有机硅（PMO）亚基组成，用于RA的早期诊断和协同治疗。Janus纳米结构，会暴露出更多的活性位点，增强ceo2−Pt纳米酶亚基的活性氧清除能力，与核心−壳部分相比。此外，从天然植物中提取具有抗破骨生成作用的化合物米甲内酯（MCL），被装载入PMO亚基的中孔中，与纳米酶的抗炎作用协同，有效治疗RA，这已被体外细胞实验和体内胶原诱导关节炎（CIA）模型证实。此外，通过利用第二近红外窗口（NIR-II）荧光成像，吲哚氰绿（ICG）负载的Janus-CPS在非常早期阶段检测RA病变方面显示出理想的效果。预计这种Janus纳米平台可能为多功能治疗学提供一种功能集成的替代策略。