何乐（Okugbe Ebiotubo Ohore），环境科学与工程博士，博士后，副研究员，硕士生导师，海南医科大学“领军人才”。    现任《Journal of Hazardous Materials》与《Science of the Total Environment》期刊编委。2017年获东南大学公共卫生硕士学位，2020 年获河海大学环境科学与工程博士学位，2021年在汕头大学从事生物学博士后研究工作。

      我的研究主要聚焦于环境污染物（如抗生素及抗生素抗性基因，ARGs）的环境归趋，以及ARGs在环境、食物与人体之间的 传播动态。同时，我关注抗生素和ARGs相关的健康风险评估，并致力于开发新型技术以减轻其不良影响并阻断其传播链。目 前，我正在研究抗生素使用对婴幼儿和成人肠道微生物群的影响，利用生物信息学、机器学习、大数据分析和人工智能等方 法，探讨从早期生命阶段到成年阶段的抗性组扩增机制。

         主要研究方向：

· 抗微生物耐药性及其从环境到人体的抗性组传播动态

· 海洋微生物学与生态学

· 感染性疾病的环境流行病学

· 宿主—微生物相互作用的基因组学与分子机制

· 公共卫生政策研究

· 大数据、人工智能在环境评估与可持续发展建模中的应用

· 化学污染物的环境归趋、迁移及风险评估

电子邮件:o.e.ohore@hainmc.edu.cn

电话:15094302142

研究方向

抗生素耐药性基因，微生物生态学，新兴污染物，健康风险评估，水质，水污染，表生生物膜，湿地。

教育背景

•中国汕头大学海洋生物学博士后

•中国河海大学环境科学与工程博士

•中国东南大学公共卫生硕士

•尼日利亚Abraka Delta State University生理学理学学士（荣誉）

主持项目：

2025-2028: 海南省高等学校科学研究项目, 抗生素对胃肠道疾病患者肠道抗生素耐药基因谱的影响, 项目编号: Hnky2025ZC-3（PI）

2023-2028：纵向科研/校级人才启动基金，项目编号：RZ2300006042，100万（PI）

202201-202512: 国家自然科学基金面上项目 (42177264)，基于线粒体功能障碍的抗生素对沿海海洋生态系统的生态效应和毒性预测， 56万元人民币。

学术兼职

2020年至今， Organization of African Academic Doctors,Kenya委员会成员

2020年至今， Think Thank常驻成员和 Organization of African Academic Doctors, Kenya颁奖委员会主席；

2023-2026《Science of the Total Environment》期刊编委成员

2023-2026《Hazardous Materials》期刊编委成员

发表论文摘选

1. Ohore, O.E., Zhang, J., Zhou, S., Sanganyado, E., Gu, J.-D., Yang, G., 2024. Tetracycline and quinolone contamination mediate microbial and antibiotic resistant gene composition in epiphytic biofilms of mesocosmic wetlands. Water Research 122484. https://doi.org/10.1016/J.WATRES.2024.122484 (第一作者，中科院1区，IF=11.4)

2. Ohore, OE., Zhang, J., Ifon, B.E., Kumwimba, M.N., Mu, X., Kuang, D., et al. 2024. Microbial phylogenetic divergence between surface-water and sedimentary ecosystems drove the resistome profiles. Science of The Total Environment. 915:170122. https://doi.org/10.1016/j.scitotenv.2024.170122 (第一作者，中科院1区，IF=8.2)

3. Ohore, O.E., Ifon, B.E., Wang, Y., Kazmi, S.S.U.H., Zhang, J., Sanganyado, E., Jiao, X., Liu, W., Wang, Z., 2023. Vertical changes in water depth and environmental variables drove the antibiotics and antibiotic resistomes distribution, and microbial food web structures in the estuary and marine ecosystems. Environment International. 178, 108118. https://doi.org/10.1016/J.ENVINT.2023.108118. (第一作者，中科院1区，IF=10.3)

4. Ohore, O.E., Wang, Y., Wei, Y., Sangayado, E., Shafiq. M., Nwankwegu, A.S., LIU. W., Wang, Z., 2023. Ecological mechanisms of sedimental microbial biodiversity shift and the role of antimicrobial resistance genes in modulating microbial turnover. Journal of Environmental Management. 325, 116547. https://doi.org/10.1016/J.JENVMAN.2022.116547. (第一作者，中科院1区，IF=8)

5. Ohore, O.E., Wei, Y., Wang, J., Wang, Y., Ifon, B.E., Liu, W., Wang, Z., 2022. Vertical characterisation of phylogenetic divergence of microbial community structures, interaction, and sustainability in estuary and marine ecosystems. Science of the Total Environment. 158369. https://doi.org/10.1016/J.SCITOTENV.2022.158369. (第一作者，中科院1区，IF=8.2)

6. Ohore, O.E., Wei, Y., Wang, Y., Nwankwegu, A.S., Wang, Z., 2022. Tracking the influence of antibiotics, antibiotic resistomes, and salinity gradient in modulating microbial community assemblage of surface water and the ecological consequences. Chemosphere 305, 135428. https://doi.org/10.1016/J.CHEMOSPHERE.2022.135428. (第一作者，中科院2区，IF=8.1)

7. Ohore, O.E., Qin, Z., Sanganyado, E., Wang, Y., Jiao, X., Liu, W., Wang, Z., 2021. Ecological impact of antibiotics on bioremediation performance of constructed wetlands: Microbial and plant dynamics, and potential antibiotic resistance genes hotspots. Journal Hazardous Materials. 424, 127495. https://doi.org/10.1016/j.jhazmat.2021.127495. (第一作者，中科院1区，IF=13.6)

8. Ohore, O.E., Zhang, S., Guo, S., Manirakiza, B., Addo, F.G., Zhang, W., 2021. The fate of tetracycline in vegetated mesocosmic wetlands and its impact on the water quality and epiphytic microbes. Journal Hazardous Materials. 417, 126148. https://doi.org/10.1016/j.jhazmat.2021.126148. (第一作者，中科院1区，IF=13.6)

9. Ohore, O.E., Zhang, S., Guo, S., Addo, F.G., Manirakiza, B., Zhang, W., 2021. Ciprofloxacin increased abundance of antibiotic resistance genes and shaped microbial community in epiphytic biofilm on Vallisneria spiralis in mesocosmic wetland. Bioresource Technology. 323, 124574. https://doi.org/10.1016/j.biortech.2020.124574. (第一作者，中科院1区，IF=9.7)

10. Ohore, O.E., Addo, F.G., Han, N., Li, X., Zhang, S., 2020. Profiles of ARGs and their relationships with antibiotics, metals and environmental parameters in vertical sediment layers of three lakes in China. Journal of Environmental Management. 255, 109583. https://doi.org/10.1016/J.JENVMAN.2019.109583. (第一作者，中科院2区，IF=8)

11. Ohore, O.E., Addo, F.G., Zhang, S., Han, N., Anim-Larbi, K., 2018. Distribution and relationship between antimicrobial resistance genes and heavy metals in surface sediments of Taihu Lake, China. Journal of Environmental Sciences. 77, 323-335. https://doi.org/10.1016/J.JES.2018.09.004. (第一作者，中科院2区，IF=5.9)

12. Ohore, O.E., Zhang, S., 2019. Endocrine disrupting effects of bisphenol A exposure and recent advances on its removal by water treatment systems. A review. Scientific African 5, e00135. Elsevier (CS=3.2) https://doi.org/10.1016/j.sciaf.2019.e00135. (第一作者，中科院2区，IF=2.7)

13. Gan, Y., Zhang, T., Cai, R., Cai, G., Ohore, O.E., Wang, H., 2024. The key monooxygenase involved in phenanthrene degradation of Ruegeria sp. PrR005. Journal Hazardous Materials, 480, 135759. https://doi.org/10.1016/J.JHAZMAT.2024.135759. (IF=13.6)

14. Cai, C., Chen, Y., Ohore, O.E., Cai, G., Cai, R., Wang, H., 2024. A sonication-filtration method for acquisition of integrated bacterial communities from phycosphere. Mar Environ Res 198, 106522. https://doi.org/10.1016/J.MARENVRES.2024.106522. (IF=3)

15. Ouyang, H., Zhao, Z., Fall, I.S., Djirmay, A.G., Ohore, O.E., Bergquist, R., Yang, G., 2024. Spatial-temporal distribution of neglected tropical diseases burdens in China from 2005 to 2020. Infect Dis Poverty 13. https://doi.org/10.1186/S40249-024-01235-Y. (IF=4.8)

16. Ifon, B.E., Adyari, B., Hou, L., Ohore, O.E., Rashid, A., Yu, C.P., Anyi, H., 2023. Urbanization influenced the interactions between dissolved organic matter and bacterial communities in rivers. Journal of Environmental Management. 341, 117986.  https://doi.org/10.1016/J.JENVMAN.2023.117986. (IF=8)

17. Nsenga Kumwimba, M., Huang, J., Dzakpasu, M., De Silva, K., Ohore, O.E., Ajibade, F.O., Li, X., Jingjun, S., Muyembe, D.K., Kaixuan, H., 2023. An updated review of the efficacy of buffer zones in warm/temperate and cold climates: Insights into processes and drivers of nutrient retention. Journal of Environmental Management. 336, 117646. https://doi.org/10.1016/J.JENVMAN.2023.117646. (IF=8)

18. Nwankwegu, A.S., Yang, G., Zhang, L., Xie, D., Ohore, O.E., Adeyeye, O.A., Li, Y., Yao, X., Song, Z., Yonas, M.W., 2023. Ecosystem anthropogenic enrichments enhance Chroococcus abundance and suppress Anabaena during cyanobacterial-dominated spring blooms in the Pengxi River, Three Gorges Reservoir, China. Marine Pollution Bulletin 193, 115141. https://doi.org/10.1016/J.MARPOLBUL.2023.115141. (IF=5.3)

19. Nwankwegu, A.S., Zhang, L., Xie, D., Ohore, O.E., Li, Y., Yang, G., Yao, X., Song, Z., Yang, Q., 2023b. Metabolites dynamics exacerbated by external nutrients inputs into a Ceratium hirundinella-dominated bloom in the Pengxi River, Three Gorges Reservoir, China. Aquatic Toxicology 258. https://doi.org/10.1016/J.AQUATOX.2023.106507. (IF=4.1)

20. Mu, X., Huang, Z., Ohore, O.E., Yang, J., Peng, K., Li, S., Li, X., 2023. Impact of antibiotics on microbial community in aquatic environment and biodegradation mechanism: a review and bibliometric analysis. Environmental Science and Pollution Research 30, 66431–66444. https://doi.org/10.1007/S11356-023-27018-W

21. Fan, H., Wang, Y., Liu. X., Wang. Y., Kazmi, S.S.U.H., Ohore, O.E., Liu, W., Wang, Z., 2022. Derivation of predicted no-effect concentrations for thirty-five pharmaceuticals and personal care products to freshwater ecosystem. Frontiers in Marine Science, 9, 1043792. https://doi.org/10.3389/fmars.2022.1043792. (IF=2.8)

22. Qin, Z., Zhao, Z., Xia, L., Ohore, O.E., 2022. Unraveling the ecological mechanisms of bacterial succession in epiphytic biofilms on Vallisneria natans and Hydrilla verticillata during bioremediation of phenanthrene and pyrene polluted wetland. Journal of Environmental Management. 321, 115986. https://doi.org/10.1016/J.JENVMAN.2022.115986. (IF=8)

23. Qin, Z., Zhao, Z., Xia, L., Ohore, O.E., 2022. Research trends and hotspots of aquatic biofilms in freshwater environment during the last three decades: a critical review and bibliometric analysis. Environmental Science and Pollution Research. 2022 1, 1–16. https://doi.org/10.1007/S11356-022-20238-6

24. Wang, Y.Y.L., Xiong, J., Ohore, O.E., Cai, Y.E., Fan, H., Sanganyado, E., Li, P., You, J., Liu, W., Wang, Z., 2022. Deriving freshwater guideline values for neonicotinoid insecticides: Implications for water quality guidelines and ecological risk assessment. Science of the Total Environment. 828, 154569. https://doi.org/10.1016/J.SCITOTENV.2022.154569. (IF= 9.8)

25. Gyawu Addo, F., Zhang, S., Manirakiza, B., Ohore, O.E., Shudong, Y., 2021. The impacts of straw substrate on biofloc formation, bacterial community and nutrient removal in shrimp ponds. Bioresouresource Technology. 326, 124727. Elsevier https://doi.org/10.1016/j.biortech.2021.124727. (IF=9.7)

26. Wang, Y.Y.L., Li, P., Ohore, O.E., Wang, Y., Zhang, D., Bai, Y., Su, T., You, J., Jin, X., Liu, W., Wang, Z., 2021. Life stage and endpoint sensitivity differences of fathead minnow (Pimephales promelas) to chemicals with various modes of action. Environmental Pollution 290, 117995. https://doi.org/10.1016/J.ENVPOL.2021.117995. (IF= 7.6)

27. Lin, D., Zhu, L., Qiu, C., Mu, X., Zhang, S., Ohore, O., 2020. Ammonium loading drives bacterial community shifts in biofilms attached to the submerged macrophyte Hydrilla verticillata. Aquatic Microbial Ecology. 85, 59–69. https://doi.org/10.3354/ame01942. (IF=1.6)

28. Si, T., Chen, H., Qiu, Z., Zhang, L., Ohore, O.E., Zhang, S., 2020. Bacterial succession in epiphytic biofilms and deciduous layer sediments during Hydrilla verticillata decay: A field investigation. Journal of Environmental Sciences. 93, 193–201. https://doi.org/10.1016/j.jes.2020.03.008. (I.F= 5.9)

29. Zhang, Z., Chen, H., Mu, X., Zhang, S., Pang, S., Ohore, O.E., 2020. Nitrate application decreased microbial biodiversity but stimulated denitrifiers in epiphytic biofilms on Ceratophyllum demersum. Journal of Environmental Management. 269, 110814. Ihttps://doi.org/10.1016/j.jenvman.2020.110814. (IF=8)

30. Yan, L., Mu, X., Han, B., Zhang, S., Qiu, C., Ohore, O.E., 2019. Ammonium loading disturbed the microbial food webs in biofilms attached to submersed macrophyte Vallisneria natans. Science of the Total Environment. 659, 691–698. https://doi.org/10.1016/J.SCITOTENV.2018.12.423. (IF=9.8)  

31. Yang, C., Yang, S., Feng, C., Zhang, C., Xu, W., Zhang, L., Yan, Y., Deng, J., Ohore, O.E., Li, J., 2018. Associations of hyperuricemia and obesity with remission of nonalcoholic fatty liver disease among Chinese men : A retrospective cohort study 1–12. PLOS ONE https://doi.org/10.1371/journal.pone.0192396. (IF:2.9)

32. Meng, W., Shen, T., Ohore, O. E., Welburn, S. C., & Yang, G. (2024). Spatiotemporal Distribution of Human Rabies and Identification of Predominant Risk Factors in China from 2004 to 2020. PLOS Neglected Tropical Diseases, 18(10), e0012557. https://doi.org/10.1371/journal.pntd.0012557

33. Zhang, J., Shang, J., Liu, B., Zhu, D., Li, Q., Yin, L., Ohore, O. E., Wen, S., Ding, C., Zhang, Y., Yue, Z., & Zou, Y. (2024). Hot spots of resistance: Transit centers as breeding grounds for airborne ARG-carrying bacteriophages. Journal of Hazardous Materials, 480, 136165. https://doi.org/10.1016/J.JHAZMAT.2024.136165