个人简介

        谷浩博士主要从事造血干细胞和白血病干细胞的干性维持机制和白血病的发生与治疗研究。共发表12篇SCI研究论文，其中以第一作者（含共同）发表4 篇，包括1篇论文以封面文章方式发表在代谢领域权威期刊Cell Metabolism (2019)，2篇论文发表在血液学领域顶级期刊Blood (2020，2024)，1篇论文发表在临床相关研究权威期刊 Journal of Clinical Investigation (2016)。

学习和工作经历

2024.11-至今 海南医科大学（海南省医学科学院）PI

2019-2024 Harvard Medical School/Dana-Farber Cancer Institute 博士后

2017-2019 上海交通大学医学院 博士后

2011-2017 中国科学院上海生命科学研究院 博士

2007-2011 华中师范大学 学士

主要获奖情况

2017 中国科学院院长优秀奖

2020 博士后创新人才支持计划优秀创新成果

研究方向

代表性成果及转化

代表性论著

1. Hao Gu, Chiqi Chen, Zhi-Shuai Hou, Xia-Di He, Shaozhen Xie, Jing Ni, Changli Qian, Xin Cheng, Tao Jiang, Ce Yang, Thomas M. Roberts, Junke Zheng, Judith A. Varner, Scott A. Armstrong, Jean J. Zhao*. PI3Kγ maintains the self-renewal of acute myeloid leukemia stem cells by regulating the pentose phosphate pathway. Blood, 2024,143(19):1965-1979.

2. Hao Gu #, Chiqi Chen #, Xiaoxin Hao #, Ni Su #, Dan Huang, Yejun Zou, Shu-Hai Lin, Xianjun Chen, Denghao Zheng, Ligen Liu, Zhuo Yu, Li Xie, Yaping Zhang, Xiaoxiao He, Xiaoyun Lai, Xiaocui Zhang, Guo-Qiang Chen, Yuzheng Zhao*, Yi Yang*, Joseph Loscalzo, Junke Zheng*. MDH1-mediated malate-aspartate NADH shuttle maintains the activity levels of fetal liver hematopoietic stem cells. Blood, 2020, 136(5): 553-571.

3. Xiaoxin Hao #, Hao Gu #, Chiqi Chen #, Dan Huang, Yuzheng Zhao, Li Xie, Yejun Zou, Hui Sophie Shu, Yaping Zhang, Xiaoxiao He, Xiaoyun Lai, Xiaocui Zhang, Guang-Biao Zhou, Cheng Cheng Zhang, Guo-Qiang Chen, Zhuo Yu*, Yi Yang*, Junke Zheng*. Metabolic Imaging Reveals a Unique Preference of Symmetric Cell Division and Homing of Leukemia-Initiating Cells in an Endosteal Niche. Cell Metabolism, 2019, 29(4): 950-965.

4. Hao Gu, Chiqi Chen, Xiaoxin Hao, Conghui Wang, Xiaocui Zhang, Zhen Li, Hongfang Shao, Hongxiang Zeng, Zhuo Yu, Li Xie, Fangzhen Xia, Feifei Zhang, Xiaoye Liu, Yaping Zhang, Haishan Jiang, Jun Zhu, Jiangbo Wan, Chun Wang, Wei Weng, Jingjing Xie, Minfang Tao, Cheng Cheng Zhang, Junling Liu*, Guo-Qiang Chen*, Junke Zheng*. Sorting protein VPS33B regulates exosomal autocrine signaling to mediate hematopoiesis and leukemogenesis. Journal of Clinical Investigation, 2016, 126(12): 4537-4553.

5. Johann S Bergholz #, Qiwei Wang #, Qi Wang #, Michelle Ramseier, Sanjay Prakadan, Weihua Wang, Rong Fang, Sheheryar Kabraji, Qian Zhou, G Kenneth Gray, Kayley Abell-Hart, Shaozhen Xie, Xiaocan Guo, Hao Gu, Thanh Von, Tao Jiang, Shuang Tang, Gordon J Freeman, Hye-Jung Kim, Alex K Shalek, Thomas M Roberts*, Jean J Zhao*. PI3Kβ controls immune evasion in PTEN-deficient breast tumours, Nature, 2023, 617(7959): 139-146.

6. Chiqi Chen #, Xiaoxin Hao #, Xiaoyun Lai #, Ligen Liu #, Jun Zhu #, Hongfang Shao, Dan Huang, Hao Gu, Tinghua Zhang, Zhuo Yu, Li Xie, Xiaocui Zhang, Yi Yang, Jun Xu*, Yuzheng Zhao*, Zhigang Lu*, Junke Zheng*. Oxidative phosphorylation enhances the leukemogenic capacity and resistance to chemotherapy of B cell acute lymphoblastic leukemia. Science Advances, 2021, 7(11): eabd6280.

7. Yaping Zhang #, Fangzhen Xia #, Xiaoye Liu #, Zhuo Yu #, Li Xie, Ligen Liu, Chiqi Chen, Haishan Jiang, Xiaoxin Hao, Xiaoxiao He, Feifei Zhang, Hao Gu, Jun Zhu, Haitao Bai, Cheng Cheng Zhang, Guo-Qiang Chen, Junke Zheng*. JAM3 maintains leukemia-initiating cell self-renewal through LRP5/AKT/β-catenin/CCND1 signaling. Journal of Clinical Investigation, 2018, 128(5): 1737- 1751.

8. Xiaoye Liu #, Feifei Zhang #, Yaping Zhang #, Xie Li, Chiqi Chen, Meiyi Zhou, Zhuo Yu, Yunxia Liu, Yuzheng Zhao, Xiaoxin Hao, Yabin Tang, Liang Zhu, Ligen Liu, Li Xie, Hao Gu, Hongfang Shao, Fangzhen Xia, Chunrong Yin, Minfang Tao, Jingjing Xie, Cheng Cheng Zhang, Yi Yang, Haipeng Sun*, Guo-Qiang Chen*, Junke Zheng*. PPM1K Regulates Hematopoiesis and Leukemogenesis through CDC20-Mediated Ubiquitination of MEIS1 and p21. Cell Reports, 2018, 23(5): 1461-1475 .

9. F Xia #, Y Zhang #, L Xie #, H Jiang #, H Zeng, C Chen, L Liu, X He, X Hao, X Fang, X Liu, F Zhang, H Gu, J Wan, Y Cheng, C C Zhang, G-Q Chen, Y Lu*, Z Yu*, J Zheng*. B7-H4 enhances the differentiation of murine leukemia-initiating cells via the PTEN/AKT/RCOR2/RUNX1 pathways. Leukemia, 2017, 31(10): 2260-2264.

10. Zhang, Feifei #, Liu, Xiaoye #, Chen, Chiqi, Zhu, Jun, Yu, Zhuo, Xie, Jingjing, Xie, Li, Bai, Haitao, Zhang, Yaping, Fang, Xia, Gu, Hao, Wang, Chun, Weng, Wei, Zhang, Cheng Cheng, Chen, Guo- Qiang*, Liang, Aibing*, Zheng, Junke*. CD244 maintains the proliferation ability of leukemia initiating cells through SHP-2/p27kip1 signaling. Haematologica, 2017, 102(4): 707-718.

11. Xia Fang, Chiqi Chen, Fangzhen Xia, Zhuo Yu, Yaping Zhang, Feifei Zhang, Hao Gu, Jiangbo Wan, Xiaocui Zhang, Wei Weng, Cheng Cheng Zhang, Guo-Qiang Chen, Aibing Liang*, Li Xie*, Junke Zheng*. CD274 promotes cell cycle entry of leukemia-initiating cells through JNK/Cyclin D2 signaling. Journal of Hematology & Oncology, 2016, 9(1): 124.

12. Jing Dai, Yeling Lu, Conghui Wang, Xue Chen, Xuemei Fan, Hao Gu, Xiaolin Wu, Kemin Wang, T Kent Gartner, Junke Zheng, Guoqiang Chen, Xuefeng Wang*, Junling Liu*. Vps33b regulates Vwf-positive vesicular trafficking in megakaryocytes. Journal of Pathology, 2016, 240(1): 108-119.

成果转化

Jean J. Zhao, Hao Gu. METHODS OF DETECTING LEUKEMIA STEM CELLS. US Patent Application no. 63/622764.

承担项目

博士后创新人才支持计划，BX201700157，VPS33B介导的骨髓微环境外泌体组分在白血病起始细胞命运决定中的功能解析, 2017/05-2019/06。