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石蓉懿，青年PI，博士生导师。主要从事白血病与机体系统性免疫研究，发现白血病发生和化疗情况下CD8+T细胞的骨髓-肠道-骨髓间运输回路，并鉴定了其对抗肿瘤免疫的重要调控作用及机制。以第一作者和（或）通讯作者在Nature Cell Biology、Nucleic Acids Research、Oncogene等期刊发表5篇SCI论文，累计发表10篇SCI论文。主持国家自然科学基金青年项目一项、博士后面上二等项目一项。
学习和工作经历
2024.08-至今 海南医科大学（海南省医学科学院）青年PI
2020.07-2024.07 上海交通大学医学院附属上海儿童医学中心 博士后
2015.09-2020.06 浙江大学 博士
2011.09-2015.06 四川农业大学 学士
主要获奖情况
2018年，浙江大学优秀研究生
2019年，浙江大学优秀研究生
2019年，国家奖学金
2020年，浙江大学优秀毕业生
石蓉懿博士致力于白血病与机体适应性免疫研究。
1. Shi, R. Y.#, Zhou, N.#, Xuan, L.#, Jiang, Z. H.#, Xia, J., Zhu, J. M., Chen, K. M., Zhou, G. L., Yu, G. P., Zhang, J., Huang, C., Liang, A. B., Liang, K. W., Zhang, H., Chen, J. F., Zhang, D., Zhong, Y.*, Liu, Q. F.*, Chen, G. Q.*, Duan, C. W.*; Trafficking circuit of CD8+ T cells between the intestine and bone marrow governs antitumour immunity. Nature Cell Biology, 2024. Aug;26(8):1346-1358.
2. Li, Q. Q.#, Guo, M. #*, He, G. H., Xi, K. H., Zhou, M. Y., Shi, R. Y.*, Chen, G. Q.*; VEGF-induced Nrdp1 deficiency in vascular endothelial cells promotes cancer metastasis by degrading vascular basement membrane. Oncogene, 2024, 43(24), 1836-1851.
3. Shi, R., Wang, Y., Gao, Y., Xu, X., Mao, S., Xiao, Y., Song, S., Wang, L., Tian, B., Zhao, Y., Hua, Y.*, Xu, H.*; Succinylation at a key residue of FEN1 is involved in the DNA damage response to maintain genome stability. Am J Physiol Cell Physiol, 2020, 319(4), C657-c666.
4. Xu, H.#, Shi, R.#, Han, W., Cheng, J., Xu, X., Cheng, K., Wang, L., Tian, B., Zheng, L., Shen, B.*, Hua, Y.*, Zhao, Y.*; Structural basis of 5' flap recognition and protein-protein interactions of human flap endonuclease 1. Nucleic Acids Research, 2018, 46(21), 11315-11325.
5. Xu, X.#, Shi, R.#, Zheng, L.#, Guo, Z.#, Wang, L., Zhou, M., Zhao, Y., Tian, B., Truong, K., Chen, Y., Shen, B.*, Hua, Y.*, Xu, H.*; SUMO-1 modification of FEN1 facilitates its interaction with Rad9-Rad1-Hus1 to counteract DNA replication stress. Journal of Molecular Cell Biology, 2018, 10(5), 460-474.
6. Xiao Y, Yin M, Wang Y, Shi R, Mao S, Hua Y, Xu H. Post-translational Modifications by Acyl Groups Regulate FEN1's Activities and Play Essential Roles in Cell Proliferation and DNA Repair. Protein Pept Lett. 2023;30(7):597-607.
7. Abudureheman T, Xia J, Li MH, Zhou H, Zheng WW, Zhou N, Shi RY, Zhu JM, Yang LT, Chen L, Zheng L, Xue K, Qing K, Duan CW. CDK7 Inhibitor THZ1 Induces the Cell Apoptosis of B-Cell Acute Lymphocytic Leukemia by Perturbing Cellular Metabolism. Front Oncol. 2021 Apr 6;11:663360.
8. Huang WL, Abudureheman T, Xia J, Chu L, Zhou H, Zheng WW, Zhou N, Shi RY, Li MH, Zhu JM, Qing K, Ji C, Liang KW, Guo S, Yin G, Duan CW. CDK9 Inhibitor Induces the Apoptosis of B-Cell Acute Lymphocytic Leukemia by Inhibiting c-Myc-Mediated Glycolytic Metabolism. Front Cell Dev Biol. 2021 Mar 4;9:641271.
9. Xu H, Chen X, Ying N, Wang M, Xu X, Shi R, Hua Y. Mass spectrometry-based quantification of the cellular response to ultraviolet radiation in HeLa cells. PLoS One. 2017 Nov 20;12(11):e0186806.
10. Xu H, Chen X, Xu X, Shi R, Suo S, Cheng K, Zheng Z, Wang M, Wang L, Zhao Y, Tian B, Hua Y. Lysine Acetylation and Succinylation in HeLa Cells and their Essential Roles in Response to UV-induced Stress. Sci Rep. 2016 Jul 25;6:30212.
1. 国家自然科学基金青年项目，82200185，免疫原性化疗趋化CXCR6+ 干细胞样CD8+ T细胞在AML治疗中的作用及机制研究，2023/1-2025/12
2. 中国博士后科学基金项目，2021M692110，骨髓血管微环境调控干细胞样CD8+ T细胞在白血病免疫原性化疗中的机制研究，2021/6-2024/6
