个人简介

谷浩，海南省医学科学院研究员、博士生导师，入选国家高层次青年人才项目。主要从事白血病发生发展、肿瘤代谢与肿瘤免疫研究，重点关注白血病干细胞、肿瘤微环境及代谢重编程，探索肿瘤复发、耐药的关键机制及新的治疗靶点。近年来围绕上述方向取得系列研究成果，相关工作发表于 Blood、Cell Metabolism、Journal of Clinical Investigation、Nature、Cell等国际期刊。主持国家自然科学基金面上项目等。

学习和工作经历

2024-至今海南医科大学（海南省医学科学院）研究员

2019-2024 美国哈佛大学医学院博士后

2017-2019 上海交通大学医学院博士后

2011-2017 中国科学院大学博士

2007-2011 华中师范大学学士

研究方向

1. 白血病干细胞与肿瘤治疗

研究急性髓系白血病、急性淋巴细胞白血病等血液肿瘤发生、复发和治疗抵抗的分子机制，重点解析白血病干细胞的自我更新和代谢依赖，寻找新的治疗靶点。

2. 肿瘤代谢与肿瘤微环境

研究肿瘤细胞如何通过糖、脂质及氧化还原代谢重编程适应微环境，以及骨髓微环境如何调控白血病干细胞的存活、自我更新和治疗反应。

3. 肿瘤免疫与代谢免疫调控

研究肿瘤细胞、免疫细胞与组织微环境之间的相互作用，解析代谢变化对抗肿瘤免疫的调控机制，并探索新的肿瘤联合治疗策略。

研究成果及转化

研究成果

1. Cheng X, Zhang Y, Qian C, Holdridge E, Ananda G, Jiang T, Ni J, Xie S, Gu H, Ji R, Ivanova EV, Nucci MR, Wang Z, Chen K, Kochupurakkal B, Freeman GJ, Shapiro GI, Liu J, Konstantinopoulos PA, Matulonis U, Zhao JJ*. Targeting FGFR signaling overcomes therapeutic resistance and immune evasion in oncogenic PIK3CA-driven serous-like endometrial cancer. Nat Commun. 2026 May 4;17(1):5994.

2. Wang Y #*, Manokaran C #, Zou Y, Chen J, Gu H, Liu D, Bousso P, Zhao JJ*, Roberts TM*. Loss of the tumor suppressor PTEN activates cell-intrinsic interferon signaling to drive immune resistance. Genes & Development, 2026 May 4;40(9-10):684-698.

3. Gu H #, Weng L #, Chen C #, Hao X #, Tao R #, Qi X #, Lai X, Liu L, Zhang T, Jiang Y, Wang J, Li WG, Yu Z, Xie L, Zhang Y, He X, Yu Y, Yang Y, Wu D, Zhao Y*, Xu TL*, Chen GQ*, Zheng J*. Nonionotropic action of an acid-sensing ion channel inhibits leukemogenesis in the acidic bone marrow niche. Journal of Clinical Investigation, 2025 Dec 15;135(24):e189051.

4. He X, Wang Q, Cheng X, Wang W, Li Y, Nan Y, Wu J, Xiu B, Jiang T, Bergholz JS, Gu H, Chen F, Fan G, Sun L, Xie S, Zou J, Lin S, Wei Y, Lee J, Asara JM, Zhang K, Cantley LC, Zhao JJ*. Lysine vitcylation is a vitamin C-derived protein modification that enhances STAT1-mediated immune response. Cell, 2025 Apr 3;188(7):1858-1877.

5. Hao Gu, Chiqi Chen, Zhi-Shuai Hou, Xia-Di He, Shaozhen Xie, Jing Ni, Changli Qian, Xin Cheng, Tao Jiang, Ce Yang, Thomas M. Roberts, Junke Zheng, Judith A. Varner, Scott A. Armstrong, Jean J. Zhao*. PI3Kγ maintains the self-renewal of acute myeloid leukemia stem cells by regulating the pentose phosphate pathway. Blood, 2024,143(19):1965-1979.

6. Johann S Bergholz #, Qiwei Wang #, Qi Wang #, Michelle Ramseier, Sanjay Prakadan, Weihua Wang, Rong Fang, Sheheryar Kabraji, Qian Zhou, G Kenneth Gray, Kayley Abell-Hart, Shaozhen Xie, Xiaocan Guo, Hao Gu, Thanh Von, Tao Jiang, Shuang Tang, Gordon J Freeman, Hye-Jung Kim, Alex K Shalek, Thomas M Roberts*, Jean J Zhao*. PI3Kβ controls immune evasion in PTEN-deficient breast tumours. Nature, 2023, 617(7959): 139-146.

7. Chiqi Chen #, Xiaoxin Hao #, Xiaoyun Lai #, Ligen Liu #, Jun Zhu #, Hongfang Shao, Dan Huang, Hao Gu, Tinghua Zhang, Zhuo Yu, Li Xie, Xiaocui Zhang, Yi Yang, Jun Xu*, Yuzheng Zhao*, Zhigang Lu*, Junke Zheng*. Oxidative phosphorylation enhances the leukemogenic capacity and resistance to chemotherapy of B cell acute lymphoblastic leukemia. Science Advances, 2021, 7(11): eabd6280.

8. Xiaoxin Hao #, Hao Gu #, Chiqi Chen #, Dan Huang, Yuzheng Zhao, Li Xie, Yejun Zou, Hui Sophie Shu, Yaping Zhang, Xiaoxiao He, Xiaoyun Lai, Xiaocui Zhang, Guang-Biao Zhou, Cheng Cheng Zhang, Guo-Qiang Chen, Zhuo Yu*, Yi Yang*, Junke Zheng*. Metabolic Imaging Reveals a Unique Preference of Symmetric Cell Division and Homing of Leukemia-Initiating Cells in an Endosteal Niche. Cell Metabolism, 2019, 29(4): 950-965.

9. Yaping Zhang #, Fangzhen Xia #, Xiaoye Liu #, Zhuo Yu #, Li Xie, Ligen Liu, Chiqi Chen, Haishan Jiang, Xiaoxin Hao, Xiaoxiao He, Feifei Zhang, Hao Gu, Jun Zhu, Haitao Bai, Cheng Cheng Zhang, Guo-Qiang Chen, Junke Zheng*. JAM3 maintains leukemia-initiating cell self-renewal through LRP5/AKT/β-catenin/CCND1 signaling. Journal of Clinical Investigation, 2018, 128(5): 1737- 1751.

10. Xiaoye Liu #, Feifei Zhang #, Yaping Zhang #, Xie Li, Chiqi Chen, Meiyi Zhou, Zhuo Yu, Yunxia Liu, Yuzheng Zhao, Xiaoxin Hao, Yabin Tang, Liang Zhu, Ligen Liu, Li Xie, Hao Gu, Hongfang Shao, Fangzhen Xia, Chunrong Yin, Minfang Tao, Jingjing Xie, Cheng Cheng Zhang, Yi Yang, Haipeng Sun*, Guo-Qiang Chen*, Junke Zheng*. PPM1K Regulates Hematopoiesis and Leukemogenesis through CDC20-Mediated Ubiquitination of MEIS1 and p21. Cell Reports, 2018, 23(5): 1461-1475.

11. F Xia #, Y Zhang #, L Xie #, H Jiang #, H Zeng, C Chen, L Liu, X He, X Hao, X Fang, X Liu, F Zhang, H Gu, J Wan, Y Cheng, C C Zhang, G-Q Chen, Y Lu*, Z Yu*, J Zheng*. B7-H4 enhances the differentiation of murine leukemia-initiating cells via the PTEN/AKT/RCOR2/RUNX1 pathways. Leukemia, 2017, 31(10): 2260-2264.

12. Zhang, Feifei #, Liu, Xiaoye #, Chen, Chiqi, Zhu, Jun, Yu, Zhuo, Xie, Jingjing, Xie, Li, Bai, Haitao, Zhang, Yaping, Fang, Xia, Gu, Hao, Wang, Chun, Weng, Wei, Zhang, Cheng Cheng, Chen, Guo- Qiang*, Liang, Aibing*, Zheng, Junke*. CD244 maintains the proliferation ability of leukemia initiating cells through SHP-2/p27kip1 signaling. Haematologica, 2017, 102(4): 707-718.

13. Xia Fang, Chiqi Chen, Fangzhen Xia, Zhuo Yu, Yaping Zhang, Feifei Zhang, Hao Gu, Jiangbo Wan, Xiaocui Zhang, Wei Weng, Cheng Cheng Zhang, Guo-Qiang Chen, Aibing Liang*, Li Xie*, Junke Zheng*. CD274 promotes cell cycle entry of leukemia-initiating cells through JNK/Cyclin D2 signaling. Journal of Hematology & Oncology, 2016, 9(1): 124.

14. Jing Dai, Yeling Lu, Conghui Wang, Xue Chen, Xuemei Fan, Hao Gu, Xiaolin Wu, Kemin Wang, T Kent Gartner, Junke Zheng, Guoqiang Chen, Xuefeng Wang*, Junling Liu*. Vps33b regulates Vwf-positive vesicular trafficking in megakaryocytes. Journal of Pathology, 2016, 240(1): 108-119.

成果转化

Jean J. Zhao, Hao Gu. METHODS OF DETECTING LEUKEMIA STEM CELLS. US Patent Application no. 63/622764.