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翟荣伟 博士

zhairongwei@muhn.edu.cn


个人简介


翟荣伟,博士,青年PI,博士生导师。主要基于非人灵长类动物模型,从事神经与精神类疾病的致病机理与治疗研究。于National Science Review、Cell  Reports、Acta Neuropathologica Communications等国际知名学术期刊上发表学术论文12篇,其中以第一/通讯作者(含共同)身份发表9篇。已获批5项国家发明专利,并先后获得国家自然科学基金、科技部项目等科研项目的支持。


学习和工作经历


2025.03-至今 海南医科大学(海南省医学科学院),青年PI,博士生导师

2022.06-2025.02 临港国家实验室,副研究员

2020.07-2022.05 中国科学院脑科学与智能技术卓越创新中心,助理研究员,副研究员

2019.03-2020.06 上海市精神卫生中心,助理研究员

2016.07-2019.02 中国科学院神经科学研究所,博士后

2008.09-2016.06 中国科学院大学,神经生物学,博士

2004.09-2008.06 安徽医科大学,生物技术,学士


研究方向


翟荣伟团队致力于神经与精神类疾病的致病机理与治疗研究。


代表性论著


1. Zhai, R.#*, Tong, G.#, Li, Z., Song, W., Hu, Y., Xu, S., Wei, Q., Zhang, X., Li, Y., Liao, B., Yuan, C., Fan, Y., Song, G., Ouyang, Y., Zhang, W., Tang, Y., Jin, M., Zhang, Y., Li, H., Yang, Z., Lin, G. N., Stein, D. J., Xiong, Z.-Q.*, & Wang, Z.* (2023). Rhesus monkeys exhibiting spontaneous ritualistic behaviors resembling obsessive-compulsive disorder. National Science Review, 10(11), nwad312. 

2. Wei, J. K.#, Wang, W. C.#, Zhai, R. W.#, Zhang, Y. H., Yang, S. C., Rizak, J., Li, L., Xu, L. Q., Liu, L., Pan, M. K., Hu, Y. Z., Ghanemi, A., Wu, J., Yang, L. C., Li, H., Lv, L. B., Li, J. L., Yao, Y. G., Xu, L., Feng, X. L., … Wang, Z. B.* (2016). Neurons Differentiated from Transplanted Stem Cells Respond Functionally to Acoustic Stimuli in the Awake Monkey Brain. Cell reports, 16(4), 1016–1025.

3. Qu, X., Yang, P., Zhai, R.*, Xiong, Z. Q.* (2024). Inhibition of RtTg Neurons Reverses Methamphetamine-Induced Attention Deficits. Acta neuropathologica communications, 12(1), 179.

4. Zhang, W., Zhou, J., Su, H., Zhang, X., Song, W., Wang, Z., Tang, C., Uludağ, K., Zhao, M., Xiong, Z. Q., Zhai, R.*, & Jiang, H.* (2023). Repeated methamphetamine exposure decreases plasma brain-derived neurotrophic factor levels in rhesus monkeys. General psychiatry, 36(5), e101127. 

5. He, L.#, Zhou, J. H.#, Li, H., Zhang, W. L., Liu, T. Q., Jiang, H. F., Zhai, R. W.*, & Zhang, X. J.* (2024). Characterization of Gut Microbiota in Rats and Rhesus Monkeys After Methamphetamine Self-administration. Molecular neurobiology, 10.1007/s12035-024-04318-x. 

6. Tang, C., Zhang, W., Zhang, X., Zhou, J., Wang, Z., Zhang, X., Wu, X., Su, H., Jiang, H., Zhai, R.*, & Zhao, M.* (2024). A 3D-Printed helmet for precise and repeatable neuromodulation targeting in awake non-human primates. Heliyon, 10(17), e37121.

7. Zhou, J., Su, H., Tang, C., Wu, X., Wang, Z., Zhang, W., Zhai, R.*, & Jiang, H.* (2024). Decreased consumption of natural rewards in rhesus monkeys with prolonged methamphetamine abstinence. Frontiers in psychiatry, 15, 1446353.

8. Zhai, R., Rizak, J., Zheng, N., He, X., Li, Z., Yin, Y., Su, T., He, Y., He, R., Ma, Y., Yang, M., Wang, Z., & Hu, X. (2018). Alzheimer's Disease-Like Pathologies and Cognitive Impairments Induced by Formaldehyde in Non-Human Primates. Current Alzheimer research, 15(14), 1304–1321.

9. Zhai, R.#, Zheng, N.#, Rizak, J., & Hu, X.* (2016). Evidence for Conversion of Methanol to Formaldehyde in Nonhuman Primate Brain. Analytical cellular pathology (Amsterdam), 2016, 4598454. 

10. Sun, Y. M., Chen, R. X., Li, Z. F., Spijker, S., Zhai, R. W., & Yang, S. C. (2018). The caudal part of the posterior insula of rats participates in the maintenance but not the acquisition of morphine conditioned place preference. CNS neuroscience & therapeutics, 24(5), 420–428. 

11. Yang, M., Miao, J., Rizak, J., Zhai, R., Wang, Z., Huma, T., Li, T., Zheng, N., Wu, S., Zheng, Y., Fan, X., Yang, J., Wang, J., Yang, S., Ma, Y., Lü, L., He, R., & Hu, X. (2014). Alzheimer's disease and methanol toxicity (part 2): lessons from four rhesus macaques (Macaca mulatta) chronically fed methanol. Journal of Alzheimer's disease : JAD, 41(4), 1131–1147.

12. Yang, M., Lu, J., Miao, J., Rizak, J., Yang, J., Zhai, R., Zhou, J., Qu, J., Wang, J., Yang, S., Ma, Y., Hu, X., & He, R. (2014). Alzheimer's disease and methanol toxicity (part 1): chronic methanol feeding led to memory impairments and tau hyperphosphorylation in mice. Journal of Alzheimer's disease : JAD, 41(4), 1117–1129. 


专利


1. 熊志奇,孙强,翟荣伟,王振,制备具有强迫仪式样行为的非人灵长类动物模型的方法。专利号:ZL201910328796.6

2.  熊志奇,翟荣伟,赵敏,一种非人灵长类药物成瘾性评估的方法与应用。专利号:ZL202011553704.3

3. 熊志奇,翟荣伟,一种灵长类动物药物成瘾性评估的装置。专利号:ZL202011553692.4

4. 熊志奇,翟荣伟,赵敏,一种非人灵长类动物物质成瘾模型的构建方法与应用。专利号:ZL202110178863.8

5. 杨上川,张玉华,翟荣伟,胡新天,检测非人灵长类动物惊吓反射的猴椅。专利号:ZL201320520404.4

6. 汤成婕,张文磊,翟荣伟,苏杭,江海峰,赵敏,一种对非人灵长类神经调控靶点进行定位的方法及装置,申请号:202410852189.0.


承担项目


1. 国家自然科学基金青年科学基金项目:强迫症猕猴模型建立、验证及rTMS治疗的神经机制研究,2021.01-2023.12,24万,已结题,主持

2. 临港国家实验室重点项目:成瘾与强迫症猴模型影像学分析,2022.01-2023.06,200万,已结题,主持

3. 上海市精神卫生中心院级重点项目:rTMS治疗强迫症的神经机制和疗效预测研究,2020.01-2022.12,20万,已结题,主持

4. 科技创新2030-“脑科学与类脑研究”重大项目:《非人灵长类模型平台》子课题《基于脑疾病模型的治疗干预手段的研发》,2021.12-2026.11,在研,课题骨干

5. 国家自然科学基金委重点项目:重复经颅磁刺激联合干预背外侧/腹内侧前额叶对甲基苯丙胺渴求环路重置的机制,2022.01-2026.12,291万,在研,骨干



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