个人简介

沈蕾，研究员，博士生导师。海南医科大学，海南省医学科学院 PI，海外高层次青年人才、上海市浦江人才。主要研究方向为免疫调控与炎症性疾病及肿瘤的基础与临床应用研究以及人体免疫组学监测。

近几年科研成果以最后通讯作者发表在 Immunity (2024)、Nature Immunology (2022) 、PNAS (2024) 、Cell Reports (2024)、Cellular&Molecular Immunology (2023) 等学术期刊 ；申请专利3项；主持国家自然科学基金面上项目、外国专家学者项目、科技部国家重点专项、上海市自然科学基金等项目。

教育和研究经历

2000-2005 美国贝勒医学院 博士后

2005-2012 美国斯坦福大学 高级科学家

2012-2024 上海交通大学医学院 上海市免疫学研究所 研究员/课题组长

2024-至今 海南医科大学 海南省医学科学院 研究员/课题组长

代表性研究论文

1.Wang H., Du Y., Huang S., et al. Single-cell analysis reveals a subpopulation of adipose progenitor cells that impairs glucose homeostasis[J]. Nature Communications, 2024, 15(1).

2.Sun J., Zhang Y., Zhang Q., et al. Metabolic regulator LKB1 controls adipose tissue ILC2 PD-1 expression and mitochondrial homeostasis to prevent insulin resistance[J]. Immunity, 2024, 57(6): 1289-1305.e1289.

3.Niu H., Zhang H., Wang D., et al. LKB1 prevents ILC2 exhaustion to enhance antitumor immunity[J]. Cell Reports, 2024, 43(5).

4.Jingjing Qi L.Y., Jiping Sun, Chuanxin Huang , Bing Su, Jinke Cheng, and Lei Shen. SUMO- specific protease 1 regulates germinal center B cell response through deSUMOylation of PAX5[J]. Proceedings of the National Academy of Sciences, 2024.

5.Xu Y., Zhang H., Wu S., et al. PLZF restricts intestinal ILC3 function in gut defense[J]. Cellular & Molecular Immunology, 2023, 20(4): 379-388.

6.Zhang J., Qiu J., Zhou W., et al. Neuropilin-1 mediates lung tissue-specific control of ILC2 function in type 2 immunity[J]. Nature Immunology, 2022, 23(2): 237-250.

7.Jiaqing Zhou J.Z., Lu Tao, Kexin Peng, Qiaoan Zhang, Kexiang Yan, Jing Luan, Jiewen Pan, Xiaohui Su, Jiping Sun,Zhenghua Zhang, Lei Shen. Up-regulation of BTN3A1 on CD14+ cells promotes Vγ9Vδ2 T cell activation in psoriasis[J]. Proceedings of the National Academy of Sciences, 2022.

8.Shen L., Ye Y., Sun H., et al. ILC3 plasticity in microbiome-mediated tumor progression and immunotherapy[J]. Cancer Cell, 2021, 39(10): 1308-1310.

9.Qiu J., Zhang J., Ji Y., et al. Tissue signals imprint Aiolos expression in ILC2s to modulate type 2 immunity[J]. Mucosal Immunology, 2021, 14(6): 1306-1322.

10.Qi J., Crinier A., Escalière B., et al. Single-cell transcriptomic landscape reveals tumor specific innate lymphoid cells associated with colorectal cancer progression[J]. Cell Reports Medicine, 2021, 2(8).

11.Liang Gao Q.Y., Huasheng Zhang, Zhengting Wang, Tianyu Zhang, Jinnan Xiang, Shuxiang Yu, Shaoyang Zhang, Hongguang Wu, Yizhou Xu, Zhuo Wang, Lu Shen, Gang Shu, Ye-Guang Chen, Huijuan Liu1, Lei Shen, Baojie Li. A resident stromal cell population actively restrains innate immune response in the propagation phase of colitis pathogenesis in mice[J]. Science Translational Medicine, 2021.

12.Li C., Liu J., Pan J., et al. ILC1s and ILC3s Exhibit Inflammatory Phenotype in Periodontal Ligament of Periodontitis Patients[J]. Frontiers in Immunology, 2021, 12.

13.Chen Z., Xie X., Jiang N., et al. CCR5 signaling promotes lipopolysaccharide-induced macrophage recruitment and alveolar developmental arrest[J]. Cell Death & Disease, 2021, 12(2).