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个人简介
李东伟 博导 海南医科大学
工作学习经历：
2025.2-至今：海南医科大学 教授 （C类人才）
2021.12-2025.3：广州医科大学 教授（第三层次）
2020.02-2021.12：中国科学院广州生物医药与健康研究院 副研究员
2018.01-2020.01：中国科学院广州生物医药与健康研究院 助理研究员
2012.06-2018.01：中国科学院大学，博士
2008.09-2012.06：河南大学生物技术系，学士
研究方向：
干细胞命运调控机制研究
心肌纤维化与再生机理研究
多组学技术研发及应用
工作业绩：
广东省杰出青年项目（2025立项），广州市卫健委优秀人才，中国科学院创新促进会会员，15期细胞黄浦研修班成员，担任中国细胞生物学会会员，广东省自然医学研究会脑科学与功能障碍防治专业委员会学术高级顾问，国际干细胞学会会员。获得科研先进个人将，吴瑞奖，中国科学院大学优秀毕业生，优秀博士毕业论文等奖项。Current Opinion in Genetics & Development期刊客座编辑，国际干细胞研究学会摘要审稿人，Bioactive Materials及Cell Bioscience期刊审稿人。在国内重要学术会议多次做主题报告。发表SCI论文27篇，其中一作/通讯SCI论文14篇，包括Cell Stem Cell, Nature Cell Biology, Nucleic Acids Research, Cell Reports, EMBO Reports等Top期刊。承担国家级和省市级科研项目9项。本人在细胞命运决定机制研究中提出染色质打开关闭规律，并指出体细胞染色质是细胞重编程障碍，优化并制定了高效高质量的iPSC制备体系。在iPSC应用中发现c-JUN是干细胞向心肌细胞分化的障碍，鉴定了小分子JNKi和KDMi可促进心肌细胞形成，近期工作显示逆转录病毒在心肌细胞命运调控中具有重要作用，建立了更加快速高效获取心肌细胞体系和逆转心肌纤维化双荧光报告系统。上述成果为未来获取更高质量心肌细胞进行心肌损伤修复打下坚实基础。
承担科研项目：
1.国家自然科学基金委；面上项目；32270574；c-JUN通过Hira调控多能干细胞增强子抑制naïve多能性重建的机理研究；2023-01至2026-12；54万；在研，主持。
2.广州市科技局；基础研究计划重点项目；2023A03J0045；c-JUN调控组蛋白MLL甲基转移酶复合物活性阻碍中胚层/心肌中胚层细胞命运决定的机制研究；2023-04至2025-03；50万；结题，主持。
3.广东省人民医院；登峰计划；DFJHBF202110；调控心肌再生的机制研究；2021-12至2025-12；60万；在研，主持。
4.国家自然科学基金委；重大研究计划；92068201；c-JUN介导心肌细胞命运决定的机制研究；2021-01至2024-12；300万；结题；承担子课题研究（150万）。
5.广东省人民医院；心血管专项；2020XXG002；c-Jun在诱导人胚胎干细胞向心肌细胞分化过程中的作用机制探索；2020-10至2023-09；60万；结题，主持。
6.国家自然科学基金委；青年科学基金；31801069；c-Jun通过调控染色质结构诱导小鼠ESC多能性退出的机理研究；2019-01至2021-12；32.4万；结题，主持。
7.中科院再生生物学重点实验室；开放课题；KLRB201802；小鼠胚胎干细胞染色质3D动态模拟；2019-01至2020-12；5万；结题，主持。
8.中科院再生生物学重点实验室；开放课题；KLRB201812；探讨尿细胞重编程多能干细胞并进一步转分化形成心肌细胞的表观遗传调控因素；2019-01至2020-12；2万；结题，主持。
9.中国科学院；2019348；中国科学院青年创新促进会会员资助；2019-01至2022-12；80万；结题，主持。
获奖及荣誉：
2024-12 广州医科大学附属第五医院 科研先进个人奖
2021-01 广东医学科技奖 一等奖（排名11）
2018-06 中国科学院大学优秀毕业生
2019-09 中国科学院优秀博士毕业论文
2018-10 吴瑞奖学金
专利：
专利名称：一种体外诱导胚胎干细胞定向分化为心肌细胞的方法；申请号：2023111117304，申请日期：2023.08.30
专利名称：一种快速在体外诱导胚胎干细胞定向分化为心肌细胞的方法；申请号：202510140533.8，申请日期：2025.02.08
人才项目：
2025 海南医科大学 C类人才
2024 广州市卫健委 优秀人才
2021 广州医科大学 南山学者 优秀人才
2019 中国科学院青年创新促进会会员
代表论著：
一作及通讯文章：
1.Ran Zhang#, Menghua Wu#, Dan Xiang#, Jieying Zhu#, Qi Zhang#, Hui Zhong#, Yuling Peng, Zhenhua Wang, Gang Ma, Guihuan Li, Fengping Liu, Weipeng Ye, Ruona Shi, Xuemeng Zhou, Isaac A. Babarinde, Huanxing Su, Jiekai Chen, Xiaofei Zhang*, Dajiang Qin*, Andrew P. Hutchins*, Duanqing Pei*,Dongwei Li*, A Primate Specific Endogenous Retroviral Envelope Protein Sequesters SFRP2 to Regulate Human Cardiomyocyte Development. Cell Stem Cell, 2024. 31(9): p. 1298-1314 e8. (IF:19.8，引用次数：1)
2.Ran Zhang#, Guihuan Li#, Qi Zhang#, Gang Ma, Zhenhua Wang, Dan Xiang, Xiaofei Zhang, Jiekai Chen, Andrew P. Hutchins, Dajiang Qin, Huanxing Su*, Duanqing Pei*, Dongwei Li*, c-Jun A Chromatin Repressor that Limits Mesoderm Differentiation in Human Pluripotent Stem Cells, Nucleic Acids Research, 2025. 53(3)(IF:16.6，引用次数：0)
3.Gang Ma#, Xiu Fu#, Lulu Zhou, Isaac A. Babarinde, Liyang Shi, Wenting Yang, Jiao Chen, Zhen Xiao, Yu Qiao, Lisha Ma, Yuhao Ou, Yuhao Li, Chen Chang, Boping Deng, Ran Zhang, Li Sun, Guoqing Tong, Dongwei Li*, Yiming Li*, Andrew P. Hutchins*, The nuclear matrix stabilizes primed-specific genes in human pluripotent stem cells. Nature Cell Biology, 2025 (IF:17.3，引用次数：0)
4.Dongwei Li#, Jing Liu#, Xuejie Yang#, Chunhua Zhou, Jing Guo, Chuman Wu, Yue Qin, Lin Guo, Jiangping He, Shenyong Yu, He Liu, Xiaoshan Wang, Fang Wu, Junqi Kuang, Andrew P. Hutchins*, Jiekai Chen*, and Duanqing Pei*, Chromatin Accessibility Dynamics during iPSC Reprogramming. Cell Stem Cell, 2017. 21(6): p. 819-833 e6. (IF:19.8，引用次数：241)
5.Shangtao Cao#, S. Shengyong Yu#, Dongwei Li#, Jing Ye, Xuejie Yang, Chen Li, Xiaoshan Wang, Yuanbang Mai, Yue Qin, Jian Wu, Jiangping He, Chunhua Zhou, He Liu, Bentian Zhao, Xiaodong Shu, Chuman Wu, Ruiping Chen, Waiyee Chan, Guangjin Pan, Jiekai Chen, Jing Liu*, and Duanqing Pei*, Chromatin Accessibility Dynamics during Chemical Induction of Pluripotency. Cell Stem Cell, 2018. 22(4): p. 529-542 e5. (IF:19.8，引用次数：87)
6.Dongwei Li#, Xiaodong Shu, Ping Zhu, and Duanqing Pei*, Chromatin accessibility dynamics during cell fate reprogramming. EMBO Reports, 2021: p. e51644. (IF:6.5，引用次数：28)
7.Yuling Peng#, Jieying Zhu#, Qi Zhang#, Ran Zhang, Zhenhua Wang, Zesen Ye, Ning Ma, Dajiang Qin, Duanqing Pei, and Dongwei Li*, Endogenous retroviral ERVH48-1 promotes human urine cell reprogramming. Cell Regeneration, 2024. 13(1). (IF:4，引用次数：0)
8.Jiantao Shi#, Qing Chen, Jianheng Lai, Jieying Zhu, Ran Zhang, Md. Abdul Mazid, Dongwei Li*, Huanxing Su*, Dajiang Qin*, Impact of C-JUN Deficiency on Thalamus Development in Mice and Human Neural Models. Cell & Bioscience, 2024. 14(1): p. 149, (IF:6.1，引用次数：0)
9.Dongwei Li#*, Ling Luo#, Lin Guo, Chuman Wu, Ran Zhang, Yuling Peng, Menghua Wu, Junqi Kuang, Yan Li, Yudan Zhang, Jun Xie, Wenxiu Xie, Rui Mao, Gang Ma, Xiuling Fu, Jiekai Chen, Andrew P. Hutchins, and Duanqing Pei, c-Jun as a one-way valve at the naive to primed interface. Cell & Bioscience, 2023. 13(1). (IF:6.1，引用次数：1)
10.Hui Zhong#, Ran Zhang#, Guihuan Li#, Ping Huang, Yudan Zhang, Jieying Zhu, Junqi Kuang, Andrew P. Hutchins, Dajiang Qin, Ping Zhu*, Duanqing Pei*, and Dongwei Li*, c-JUN is a barrier in hESC to cardiomyocyte transition. Life Science Alliance, 2023. 6(11). (IF:3.3，引用次数：9)
11.Ping Huang#, Jieying Zhu, Yu Liu, Guihuan Liu, Ran Zhang, Dongwei Li*, Duanqing Pei*, and Ping Zhu*, Identification of New Transcription Factors that Can Promote Pluripotent Reprogramming. Stem Cell Reviews and Reports, 2021. 17(6): p. 2223-2234. (IF:4.5，引用次数：3)
12.Bo Wang#, Linlin Wu#, Dongwei Li#, Yuting Liu, Jing Guo, Chen Li, Yuxiang Yao, Yaofeng Wang, Guoqing Zhao, Xiaoshan Wang, Meijun Fu, He Liu, Shangtao Cao, Chuman Wu, Shengyong Yu, Chunhua Zhou, Yue Qin, Junqi Kuang, Jin Ming, Shilong Chu, Xuejie Yang, Ping Zhu, Guangjin Pan, Jiekai Chen, Jing Liu*, and Duanqing Pei*, Induction of Pluripotent Stem Cells from Mouse Embryonic Fibroblasts by Jdp2-Jhdm1b-Mkk6-Glis1-Nanog-Essrb-Sall4. Cell Reports, 2019. 27(12): p. 3473-3485.e5. (IF:7.5，引用次数：57)
13.Dongwei Li#, Jiekai Chen, and Duanqing Pei*, The Battle between TET Proteins and DNA Methylation for the Right Cell. Trends Cell Biology, 2018. 28(12): p. 973-975. (IF:13，引用次数：10)
14.李东伟，陈捷凯，裴端卿, 诱导重编程的表观遗传调控研究进展. 生命科学, 2017. 29(10). (IF:0.88，引用次数：0)
参与文章：
15. Lin R., Z. Zhai, J. Kuang, C. Wu, Y. Yao, R. Shi, J. He, S. Xu, P. Li, Y. Fan, W. Li, Z. Wu, X. Li, J. Ming, J. Guo, B. Wang, D. Li, S. Cao, X. Zhang, Y. Li, D. Pei, and J. Liu, H3K27ac mediated SS18/BAFs relocation regulates JUN induced pluripotent-somatic transition. Cell Biosci, 2022. 12(1): p. 89.
16. Liu P., S. Chen, Y. Wang, X. Chen, Y. Guo, C. Liu, H. Wang, Y. Zhao, D. Wu, Y. Shan, J. Zhang, C. Wu, D. Li, Y. Zhang, T. Zhou, Y. Chen, X. Liu, C. Li, L. Wang, B. Jia, J. Liu, B. Feng, J. Cai, and D. Pei, Efficient induction of neural progenitor cells from human ESC/iPSCs on Type I Collagen. Sci China Life Sci, 2021. 64(12): p. 2100-2113.
17. Kuang J., Z. Zhai, P. Li, R. Shi, W. Guo, Y. Yao, J. Guo, G. Zhao, J. He, S. Xu, C. Wu, S. Yu, C. Zhou, L. Wu, Y. Qin, B. Cai, W. Li, Z. Wu, X. Li, S. Chu, T. Yang, B. Wang, S. Cao, D. Li, X. Zhang, J. Chen, J. Liu, and D. Pei, SS18 regulates pluripotent-somatic transition through phase separation. Nat Commun, 2021. 12(1): p. 4090.
18. Wu K., H. Liu, Y. Wang, J. He, S. Xu, Y. Chen, J. Kuang, J. Liu, L. Guo, D. Li, R. Shi, L. Shen, Y. Wang, X. Zhang, J. Wang, D. Pei, and J. Chen, SETDB1-Mediated Cell Fate Transition between 2C-Like and Pluripotent States. Cell Rep, 2020. 30(1): p. 25-36 e6.
19. Bredenkamp N., J. Yang, J. Clarke, G.G. Stirparo, F. von Meyenn, S. Dietmann, D. Baker, R. Drummond, Y. Ren, D. Li, C. Wu, M. Rostovskaya, S. Eminli-Meissner, A. Smith, and G. Guo, Wnt Inhibition Facilitates RNA-Mediated Reprogramming of Human Somatic Cells to Naive Pluripotency. Stem Cell Reports, 2019.
20. Zhang T., K. Huang, Y. Zhu, T. Wang, Y. Shan, B. Long, Y. Li, Q. Chen, P. Wang, S. Zhao, D. Li, C. Wu, B. Kang, J. Gu, Y. Mai, Q. Wang, J. Li, Y. Zhang, Z. Liang, L. Guo, F. Wu, S. Su, J. Wang, M. Gao, X. Zhong, B. Liao, J. Chen, X. Zhang, X. Shu, D. Pei, J. Nie, and G. Pan, Vitamin C-dependent lysine demethylase 6 (KDM6)-mediated demethylation promotes a chromatin state that supports the endothelial-to-hematopoietic transition. J Biol Chem, 2019. 294(37): p. 13657-13670.
21. Guo L., L. Lin, X. Wang, M. Gao, S. Cao, Y. Mai, F. Wu, J. Kuang, H. Liu, J. Yang, S. Chu, H. Song, D. Li, Y. Liu, K. Wu, J. Liu, J. Wang, G. Pan, A.P. Hutchins, J. Liu, D. Pei, and J. Chen, Resolving Cell Fate Decisions during Somatic Cell Reprogramming by Single-Cell RNA-Seq. Mol Cell, 2019. 73(4): p. 815-829 e7.
22. Wang B., D. Li, J. Chen, J. Liu, and D. Pei, Mouse embryonic stem cells resist c-Jun induced differentiation when in suspension. Cell Regen (Lond), 2018. 7(1): p. 16-21.
23. Hutchins A.P., Z. Yang, Y. Li, F. He, X. Fu, X. Wang, D. Li, K. Liu, J. He, Y. Wang, J. Chen, M.A. Esteban, and D. Pei, Models of global gene expression define major domains of cell type and tissue identity. Nucleic Acids Res, 2017. 45(5): p. 2354-2367.
24. Cao S., S. Yu, Y. Chen, X. Wang, C. Zhou, Y. Liu, J. Kuang, H. Liu, D. Li, J. Ye, Y. Qing, S. Chu, L. Wu, L. Guo, Y. Li, X. Shu, J. Chen, J. Liu, and D. Pei, Chemical reprogramming of mouse embryonic and adult fibroblast into endoderm lineage. J Biol Chem, 2017.
25. Liu J., Q. Han, T. Peng, M. Peng, B. Wei, D. Li, X. Wang, S. Yu, J. Yang, S. Cao, K. Huang, A.P. Hutchins, H. Liu, J. Kuang, Z. Zhou, J. Chen, H. Wu, L. Guo, Y. Chen, Y. Chen, X. Li, H. Wu, B. Liao, W. He, H. Song, H. Yao, G. Pan, J. Chen, and D. Pei, The oncogene c-Jun impedes somatic cell reprogramming. Nature Cell Biology, 2015. 17(7): p. 856-67.
26. Chen J., H. Liu, J. Liu, J. Qi, B. Wei, J. Yang, H. Liang, Y. Chen, J. Chen, Y. Wu, L. Guo, J. Zhu, X. Zhao, T. Peng, Y. Zhang, S. Chen, X. Li, D. Li, T. Wang, and D. Pei, H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs. Nat Genet, 2013. 45(1): p. 34-42.
27. Li Sun, Xiuling Fu, Zhen Xiao, Gang Ma, Yibin Zhou, Haoqing Hu, Liyang Shi, Dongwei Li, Ralf Jauch, Andrew Paul Hutchins, BRD8 guards the pluripotent state by sensing and maintaining histone acetylation, Advanced Science, 2024. PMID: 39656858 DOI: 10.1002/advs.202409160
