个人简介

杨悦，海南医科大学海南省医学科学院，助理研究员。主要从事高通量小分子抑制剂筛选、基因编辑工具开发与应用，重点关注CRISPR-Cas蛋白的小分子抑制剂筛选和作用机制研究、碱基编辑器编辑窗口调控。研究成果发表于Molecular Therapy、Protein & Cell、Cells、Cell & bioscience、Kidney International Reports等杂志。申请中国发明专利7项（授权4项），主持广东省面上项目一项。

学习和工作经历

2026—至今   海南医科大学海南省医学科学院  助理研究员

2023—2026   中山大学附属第一医院  博士后

2018—2022   中山大学  生物化学与分子生物学  博士

2015—2018  华中师范大学  应用化学  硕士

2011—2015   华中农业大学  应用化学  学士

研究方向

基因编辑工具开发与应用、CRISPR-Cas系统调控、高通量小分子抑制剂筛选、肾病生物标志物鉴定

代表性论著

1.  Yang Y^#, Fu ZH, Deng SC, Wu GL, Wang CL, Luo X, Kang R, Chen YX, Peng CX, Zhang PF, Cui KX, Wan F, Wang JH, Zhou Q, Chen W, Xiong YY, Ma WB, Songyang Z*, Liang PP*. RNA-DNA hybrid binding domain broadens the editing window of base editors [J]. Molecular Therapy, 2025, 33(9): 4431-4446. PMID: 40518666.

2.  Yang Y^#, Li D^#, Wan F, Chen B, Wu G, Li F, Ren Y, Liang P, Wan J*, Songyang Z*. Identification and Analysis of Small Molecule Inhibitors of CRISPR-Cas9 in Human Cells [J]. Cells, 2022, 11(22). PMID: 31115790.

3.  Wang J H^#, Wei Q S^#, Yang Y^#, Che M T, Ma Y H, Peng L Z, Yu H Y, Shi H J, He G H, Wu R J, Zeng T, Zeng X*, Ma W B*. Small extracellular vesicles derived from four dimensional-culture of mesenchymal stem cells induce alternatively activated macrophages by upregulating IGFBP2/EGFR to attenuate inflammation in the spinal cord injury of rats [J]. Frontiers in Bioengineering and Biotechnology, 2023, 11. PMID: 37187882.

4.  Xu M H^#, Yang Y^#, Zhang PH, Zhou CX, Zhou Q*, Luo N*. Identifying Circ-RNF216 as a Regulator of Renal Tubular Epithelial Cell Proliferation Via the TGF-Β1/Smad3-Mediated Pathway in Chronic Kidney Disease [J]. Cellular Physiology and Biochemistry, 2025, 59: 867-883.

5.  Zhu J, Sun T, Wei F, Wang D, Liu F, Chen D, Liu X, Wang C, Deng S, Yang Y, Xiong Y, Xiang H, Li J, Li S, Ma W, Zhou S. Targeting ROAM1 with UDP-GlcNAc nanosheets selective activates lysosomal AMPK to resolve metabolic dysfunction-associated steatotic liver disease. Bioactive Materials, 2026, 66:487-507. PMID: 42518659.

6.  Wang C, Chen W, Li R, Yang Y, Wu J, Tian Y, He Z, Lin S, Wang X, Zhu J, Ma W, Songyang Z, Huang Y. Disruption of ZC3H15 compromises telomere length maintenance by entrapping telomerase within cajal bodies [J]. Cell & bioscience. 2025, 15(1):107. PMID: 40696438.

7.  Ma D^#, Wang D^#, Yu J, Huang N, Luo N, Yang Y, Xu M, Li J, Qiu Y, Fan J, Li Z, Chen W*, Zhou Q*. Single-Cell Profiling of Tubular Epithelial Cells in Adaptive State in the Urine Sediment of Patients With Early and Advanced Diabetic Kidney Disease [J] Kidney International Reports, 2024, 10(3): 892-905. PMID: 40225386.

8.  Wang C^#, Huang Y^#*, Yang Y, Li R, Li Y, Qiu H, Wu J, Shi G, Ma W, Songyang Z*. ILF3 safeguards telomeres from aberrant homologous recombination as a telomeric R-loop reader [J]. Protein & Cell, 2024, 15(7): 493-511. PMID: 37991243.

9.  Liu J#, Chen Y#, Nong B, Luo X, Cui K, Li Z, Zhang P, Tan W, Yang Y, Ma W, Liang P*, Songyang Z*. CRISPR-assisted transcription activation by phase-separation proteins [J]. Protein & Cell, 2023, 14(12): 874-887. PMID: 36905356.

10.  Chen Y^#, Kang R^#, Jiang Y^#, Zheng Q^#, Yang Y, Liu J, Wu G, Zhao W, Li Z, Peng C, Zhang P, Peng F, Liu Q, Hu S, Luo X, Wu G, Cui K, Huang J, Wang Y, Songyang Z, Liang P*. Rationally designed Campylobacter jejuni Cas9 enables efficient gene activation and base editing [J]. Molecular Therapy-Nucleic Acids. 2024, 18;35(4):102366. PMID: 39558904.

11.    Liang P, Zhang PF, Chen YX, Zhao WJ, Zhang YQ, Li A, Wu GL, Yang Y, Jiang RW, Wu S, Fu ZH, Peng F, Wang SQ, Luo X, Deng HF, Peng CX, Wang XC, Gao J, Hu Y, Yang H, Liu KH, Tong HW, Songyang Z. Development of B-to-A base editors by leveraging translesion synthesis polymerase [J]. 27 July 2025, PREPRINT (Version 1) available at Research Square.（预印本）

12.  Chen H^#, Han X^#, Qin N^#, Wei L, Yang Y, Rao L, Chi B, Feng L, Ren Y*, Wan J*. Synthesis and biological evaluation of novel inhibitors against 1,3,8-trihydroxynaphthalene reductase from Magnaporthe grisea [J]. Bioorganic & Medicinal Chemistry. 2016 15;24(6):1225-1230. PMID: 26860927.

专利

1. 万坚、任彦亮、万芬、杨悦、肖闪、魏林、朱秀云、饶立、冯玲玲、黄运远，苯肼基酮类化合物在作为农用杀菌剂的用途，ZL201710551882.4 

2. 松阳洲、杨悦、梁普平、刘嘉琪，一种Cas蛋白活性抑制剂及其应用，ZL202211275199.X 

3. 松阳洲、杨悦、何梓彬、马文宾、梁普平、陈昱僖，一种用于检测CRISPR-Cas蛋白切割活性的双荧光素酶报告细胞系及其应用，ZL202211255343.3 

4. 松阳洲、杨悦、彭程祥，一种融合蛋白及其应用，ZL202411402674.4 

5. 松阳洲、杨悦、付子豪，一种腺嘌呤单碱基编辑系统及其应用，202511579631.8 

6. 松阳洲、杨悦，10-羟基喜树碱在抑制SpCas9活性中的应用，202610546940.3 

7. 松阳洲、杨悦，二氢丹参酮I在抑制SpCas9活性中的应用，202610546937.1 

承担项目

1. R-loop结合结构域“双向调控”碱基编辑器编辑窗口的机制及应用研究，广东省自然科学基金-面上项目，2026.01-2028.12，10万元，主持。