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王洪亮，教授、博士生导师。主要从事病原与宿主相互作用研究，包括病毒性疾病致病与防治方法、噬菌体感染及噬菌体疗法等。兼任中国微生物学会医学微生物学与免疫学专业委员会委员；中华医学会医学病毒学分会委员；陕西省微生物学会副理事长；陕西省细胞生物学会理事；陕西省医学会微生物学与免疫学分会常务委员等。
2025.05-至今 海南省医学科学院，PI
2023.11-至今 西安交通大学第一附属医院，教授
2017.11-2025.07 西安交通大学医学院，教授
2016.06-2018.02 密歇根大学医学院，Lab Specialist
2011.05-2016.05 密歇根大学医学院，Research Fellow
2009.09-2011.05 中美冠科生物技术有限公司，科学家
2004.08-2009.08 北京协和医学院基础学院，博士
1999.08-2004.07 山东大学齐鲁医学院，本科
病毒传染性疾病致病机制与防治方法；噬菌体感染机制与噬菌体疗法
1. The class III phosphatidylinositol 3-kinase VPS34 supports EV71 replication by promoting viral replication organelle formation. B Wu, T Fan, X Chen, Y He*, H Wang*, Journal of Virology ,2024
2. N-terminal acetyltransferase 6 facilitates enterovirus 71 replication by regulating PI4KB expression and replication organelle biogenesis. H Yang, T Fan, M Xun, B Wu, S Guo, X Li, X Zhao, H Yao, H Wang*, Journal of Virology ,2024
3. Cathelicidin peptide analogues inhibit EV71 infection through blocking viral entry and uncoating.T Fan, B Liu, H Yao, X Chen, H Yang, S Guo, B Wu, X Li, X Li, M Xun*, H Wang*. PLoS Pathogens , 2024
4. Construction of coxsackievirus B5 viruses with luciferase reporters and their applications in vitro and in vivo. S Guo, M Xun, T Fan, X Li, H Yao, X Li, B Wu, H Yang, C Ma, H Wang*, Virologica Sinica ,2023
5. MAVS-based reporter systems for real-time imaging of EV71 infection and antiviral testing, X Li, E Yang, X Li, T Fan, S Guo, H Yang, B Wu, H Wang*, Viruses, 2023
6. Spike protein mediated membrane fusion during SARS‐CoV‐2 infection, X Li, H Yuan, X Li, H Wang*, Journal of medical virology ,2023
7. Cytoplasmic domain and enzymatic activity of ACE2 are not required for PI4KB dependent endocytosis entry of SARS-CoV-2 into host cells, H Yang, H Yuan, X Zhao, M Xun, S Guo, N Wang, B Liu, H Wang*, Virologica Sinica ,2022
8. N-Acetyltransferase 8 Promotes Viral Replication by Increasing the Stability of Enterovirus 71 Nonstructural Proteins. X Zhao, H Yuan, H Yang, Y Liu, M Xun, X Li, T Fan, B Wu, S Guo, H Wang*, Journal of virology ,2022
9. Bacteriophage protein Gp46 is a cross-species inhibitor of nucleoid-associated HU proteins. P Zhang, X Zhao, Y Wang, K Du, Z Wang, J Yu, G Chang, S Matthews, H Wang*, B Liu*. PNAS ,2022
10. Rapid quantitative monitoring of SARS‐CoV‐2 spike protein mediated syncytia formation using split NanoLuc. H Wang*, S Guo, H Yang, Journal of Medical Virology, 2022
11. Nir2 is an effector of VAPs necessary for efficient hepatitis C virus replication and phosphatidylinositol 4-phosphate enrichment at the viral replication organelle. H Wang, AW Tai*, Journal of Virology ,2019
12. Continuous de novo generation of spatially segregated hepatitis C virus replication organelles revealed by pulse-chase imaging, H Wang, AW Tai*. Journal of hepatology ,2017
13. Oxysterol-binding protein is a phosphatidylinositol 4-kinase effector required for HCV replication membrane integrity and cholesterol trafficking, H Wang, JW Perry, AS Lauring, P Neddermann, R De Francesco, AW Tai*. Gastroenterology ,2014
14. Rab18 binds to hepatitis C virus NS5A and promotes interaction between sites of viral replication and lipid droplets, S Salloum*, H Wang*, C Ferguson, RG Parton, AW Tai. PLoS pathogens, 2013
15. Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury, Y Imai*, K Kuba, GG Neely, R Yaghubian-Malhami, T Perkmann, G Loo, M Ermolaeva, R Veldhuizen, YH Leung, H Wang, H Liu, Y Sun, M Pasparakis, M Kopf, C Mech, S Bavari, JS Peiris, A Slutsky, S Akira, M Hultqvist, R Holmdahl, J Nicholls, C Jiang, C Binder, J Penninger*. Cell ,2008
16. SARS coronavirus entry into host cells through a novel clathrin-and caveolae-independent endocytic pathway, H Wang, P Yang, K Liu, F Guo, Y Zhang, G Zhang, C Jiang*. Cell research, 2008
1. 国家自然科学基金面上项目，81871662，脂质转运蛋白与VAMP相关蛋白相互作用维持丙型肝炎病毒复制体脂质组分的分子机制，201901-202212, 负责人;
2. 国家自然科学基金面上项目，82272309，N-乙酰转移酶8促进肠道病毒A71型感染的分子机制研究，202301-202612, 负责人。
3. 陕西省杰出青年基金，2024JC-JCQN-72，新型冠状病毒膜融合机制研究及新型膜融合抑制剂类抗病毒药物筛选，202401-202612, 负责人。
4. 国家自然科学基金专项项目，82150201，双重阻断新冠病毒膜融合的小分子有效拮抗剂筛选与发现，202201-202412,子课题负责人。
5. 国家重点研发计划, 2025YFC3408501，安全高效噬菌体制剂研发及临床治疗耐药菌感染关键技术研究, 研究骨干
6. 医学分子生物学国家重点实验室开放课题项目，含有荧光素酶报告基因的全长、可感染乙肝病毒模型的建立及初步应用探索，201901-202001，负责人。
7. 秦农银行新冠专项项目，新型冠状病毒刺突蛋白与其体外存活能力、传播感染能力关系研究，2020-2022, 负责人。
8. 陕西力邦制药横向课题，含碘无纺布对病毒的抑制作用浓度探索性研究，2020, 负责人。
